ArticleBMJ open2021
Value of age and alarm features for predicting upper gastrointestinal malignancy in patients with dyspepsia: an endoscopic database review of 4664 patients in Thailand.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Dyspepsia Care as a Missed Gateway to Gastric Cancer Prevention in High-Risk U.S. Populations.Journal of immigrant and minority health · 2026Article
- Setting a Standard for Helicobacter pylori Management in Pakistan.The Korean journal of helicobacter and upper gastrointestinal research · 2026Article
- Additional Role of Transabdominal Ultrasonography on Esophagogastroduodenoscopy for Uninvestigated Dyspepsia: A Prospective Study.Gastroenterology research and practice · 2026Article
- Age- and Risk-Based Stratification in Dyspepsia: Redefining Endoscopic Thresholds for Clinically Significant and Malignant Findings.Clinics and practice · 2025Article
- Prevalence and factors associated with organic dyspepsia in older adults with dyspepsia.Scientific reports · 2025Article
- Endoscopic Findings in Patients Presenting Dyspepsia: A Population-Based Study in Mashhad, North East of Iran.Middle East journal of digestive diseases · 2025Article
- Epidemiology of Disorders of the Gut-Brain Interaction: An Appraisal of the Rome IV Criteria and Beyond.Gut and liver · 2024Review
- Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia.World journal of gastroenterology · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAge and alarm features are commonly used as indicators for endoscopy in dyspeptic patients; however, the age cut-off and the predictive value of these parameters for identifying upper gastrointestinal (UGI) malignancies are uncertain.
designCross-sectional study.
settingData were extracted from the Gastrointestinal Endoscopy Centre of Siriraj Hospital, Thailand, during 2005-2011.
participantsConsecutive patients underwent a first-time upper endoscopy for dyspepsia. Patients with previous surgery, suspected UGI malignancy by imaging, or indefinite biopsy results on prior examination were excluded.
main outcome measuresAlarm features included dysphagia, unintentional weight loss, GI bleeding/anaemia, and persistent vomiting. The diagnostic performance of each alarm feature and different age cut-off values were evaluated.
resultsA total of 4664 patients (mean age: 52.0±14.4 years, 66% female) were included. Alarm symptoms were presented in 21.6%. The prevalence of active
conclusionDespite the overall limited value of age and alarm features, persistent vomiting, dysphagia, and GI bleeding/anaemia are strong predictors for malignancy in patients aged <50 years. Without these symptoms, cancer prevalence is negligible; thus, they are worthy guidance for endoscopic evaluation in this age group.
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