Evidence map›Paper›PMID 34706869›Full record

ArticleGut2022

MicroRNA-206 promotes the recruitment of CD8

Ningning Liu, Xiaomei Wang, Clifford John Steer, Guisheng Song

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Ripk2 promotes CD8Cell death & disease · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Exploration (Beijing, China) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ningning LiuDepartment of Medicine, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.ORCID 0000-0002-3868-8395
Xiaomei WangDepartment of Medicine, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Clifford John SteerDepartment of Medicine, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Guisheng SongDepartment of Medicine, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA gsong@umn.edu.ORCID 0000-0002-7309-4170
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveKupffer cells (KCs) protect against hepatocellular carcinoma (HCC) by communicating with other immune cells. However, the underlying mechanism(s) of this process is incompletely understood.

designFVB/NJ mice were hydrodynamically injected with AKT/Ras and

resultsHydrodynamic injection of AKT/Ras into mice drove M2 polarisation of KCs and depletion of cytotoxic T cells (CTLs) and promoted HCC development. M1-to-M2 transition of KCs impaired microRNA-206 biogenesis. By targeting

conclusionsM2 polarisation of KCs is a major contributor of HCC in AKT/Ras mice. MicroRNA-206, by driving M1 polarisation of KCs, promoted the recruitment of CD8

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMicroRNAsAnimalsCD8-Positive T-LymphocytesChemokinesKupffer CellsMiceProto-Oncogene Proteins c-aktChemokinesMicroRNAsMirn206 microRNA, mouseProto-Oncogene Proteins c-akthepatocellular carcinomaimmunotherapyKupffer cell

Identifiers

PMID34706869
PMCPMC9279850
OpenAlexW3208016850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.