ReviewParasites & vectors2021
On the role of dauer in the adaptation of nematodes to a parasitic lifestyle.
Review in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Impact of temperature and pH variations on intergeneric interactions and proteomic responses in rhabditid nematodes.Archives of microbiology · 2026Article
- Differential Phoretic Vector Use Among SympatricEcology and evolution · 2026Article
- Article
- Caenorhabditis elegans populations shape their microbial environment.NPJ biofilms and microbiomes · 2026Article
- Nictation behavior in nematodes.BMC biology · 2025Review
- From Worms to Tumors: Conserved Strategies of Cellular Arrest and Survival Governing Dormancy.Cancer research · 2025Review
- Pelodera: cosmopolitan phoretic saprotrophs and neglected models for origins of nematode parasitism.Parasites & vectors · 2025Review
- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.PLoS pathogens · 2025Article
- The fourth-stage autoinfective larva ofJournal of clinical microbiology · 2025Article
- The many roads toJournal of biosciences · 2025Review
- Isolation, morphological, and molecular characterization of a nativeFrontiers in plant science · 2025Article
- Analysis of the sulfate permease family inFrontiers in plant science · 2025Article
- Emergence of dauer larvae in Caenorhabditis elegans disrupts continuity of host-microbiome interactions.FEMS microbiology ecology · 2024Article
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- Robustness and variability inbioRxiv : the preprint server for biology · 2024Article
- A revision of the trichostrongylid nematodeFrontiers in veterinary science · 2024Article
- Article
- Filarial DAF-12 sense the host serum to resume iL3 development during infection.PLoS pathogens · 2023Article
- Breaking spore dormancy in budding yeast transforms the cytoplasm and the solubility of the proteome.PLoS biology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Nematodes are presumably the most abundant Metazoa on Earth, and can even be found in some of the most hostile environments of our planet. Various types of hypobiosis evolved to adapt their life cycles to such harsh environmental conditions. The five most distal major clades of the phylum Nematoda (Clades 8-12), formerly referred to as the Secernentea, contain many economically relevant parasitic nematodes. In this group, a special type of hypobiosis, dauer, has evolved. The dauer signalling pathway, which culminates in the biosynthesis of dafachronic acid (DA), is intensively studied in the free-living nematode Caenorhabditis elegans, and it has been hypothesized that the dauer stage may have been a prerequisite for the evolution of a wide range of parasitic lifestyles among other nematode species. Biosynthesis of DA is not specific for hypobiosis, but if it results in exit of the hypobiotic state, it is one of the main criteria to define certain behaviour as dauer. Within Clades 9 and 10, the involvement of DA has been validated experimentally, and dauer is therefore generally accepted to occur in those clades. However, for other clades, such as Clade 12, this has hardly been explored. In this review, we provide clarity on the nomenclature associated with hypobiosis and dauer across different nematological subfields. We discuss evidence for dauer-like stages in Clades 8 to 12 and support this with a meta-analysis of available genomic data. Furthermore, we discuss indications for a simplified dauer signalling pathway in parasitic nematodes. Finally, we zoom in on the host cues that induce exit from the hypobiotic stage and introduce two hypotheses on how these signals might feed into the dauer signalling pathway for plant-parasitic nematodes. With this work, we contribute to the deeper understanding of the molecular mechanisms underlying hypobiosis in parasitic nematodes. Based on this, novel strategies for the control of parasitic nematodes can be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.