ArticleEnvironmental health : a global access science source2021
Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study.
Article in Environmental health : a global access science source, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Epidemiology and Risk Factors for Testicular Cancer: A Systematic Review.European urology · 2025Pooled it
- Residence Near Agricultural Crops at Birth and Risk of Adult Testicular Germ Cell Tumors: A French Nationwide Case-Control Study Using Historical Aerial GIS Data.International journal of cancer · 2026Article
- Endocrine-Disrupting Pesticides as Drivers of Human Disease: Mechanistic Toxicology and Life-Course Health Effects.International journal of molecular sciences · 2026Review
- Parental occupational exposure to pesticides at birth and risk of adult testicular germ cell tumours in offspring: a French nationwide case-control study.Occupational and environmental medicine · 2026Article
- Multifaceted mechanisms by which environmental endocrine-disrupting chemicals promote cancer progression: crosstalk among carcinogenesis, immunity, and metabolic reprogramming: narrative mini-review.Frontiers in molecular biosciences · 2026Review
- Giant seminoma of the testis (2.51 kg) in a setting of severe occupational and lifestyle exposures: a case report and pathophysiological insights.Frontiers in medicine · 2026Article
- Dietary Exposure to Pesticide and Veterinary Drug Residues and Their Effects on Human Fertility and Embryo Development: A Global Overview.International journal of molecular sciences · 2024Review
- Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.Scandinavian journal of work, environment & health · 2024Article
- Imprinting and Reproductive Health: A Toxicological Perspective.International journal of molecular sciences · 2023Review
- Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study).Scandinavian journal of work, environment & health · 2023Article
- Environmental oestrogens disrupt testicular descent and damage male reproductive health: Mechanistic insight.Journal of cellular and molecular medicine · 2023Review
- Testicular germ cell tumour risk by occupation and industry: a French case-control study - TESTIS.Occupational and environmental medicine · 2023Article
- Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case-control study.Frontiers in public health · 2023Article
- Environmental disruptors and testicular cancer.Endocrine · 2022Review
- Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France.Cancers · 2022Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundTesticular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development.
methodsWe conducted a case-control study of 304 TGCT cases, aged 18-45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants' mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son's birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression.
resultsPrevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80-2.01) or herbicides (OR = 1.15, CI = 0.67-2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04-2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26-4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06-5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12-3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype.
conclusionsAlthough recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.
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Registered trials
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