Evidence map›Paper›PMID 34706651›Full record

ArticleBMC neurology2021

MOG antibody-associated encephalitis secondary to Covid-19: case report.

Ervin Durovic, Corinna Bien, Christian G Bien, Stefan Isenmann

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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  10. Movement Disorders and SARS-CoV-2.Movement disorders clinical practice · 2023
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  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ervin DurovicDepartment of Neurology, Klinik für Neurologie und klinische Neurophysiologie, St. Josef Krankenhaus Moers, Asbergerstr. 4, 47441, Moers, Germany.
Corinna BienLaboratory Krone, Bad Salzuflen, Germany.
Christian G BienDepartment of Epileptology (Krankenhaus Mara), Bielefeld University, Medical School, Campus Bielefeld-Bethel, Bielefeld, Germany.ORCID https://orcid.org/0000-0003-2225-8654
Stefan IsenmannDepartment of Neurology, Klinik für Neurologie und klinische Neurophysiologie, St. Josef Krankenhaus Moers, Asbergerstr. 4, 47441, Moers, Germany. stefan.isenmann@st-josef-moers.de.ORCID http://orcid.org/0000-0003-1941-5487
Bielefeld University · DESt. Josef Krankenhaus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile Covid-19 predominantly affects the respiratory system, neurological manifestations including encephalitis occur in some patients, possibly affecting the course and outcome of the disease. Here, we describe a unique case of a young man with Covid-19 and transient MOG-positive encephalitis, with a benign course. CASE PRESENTATION: A 22-year-old male, with PCR confirmed Covid-19 infection was admitted because of persistent headache. The clinical examination was normal. Neuropsychological testing revealed distinct executive deficits. Brain MRI and cerebrospinal fluid (CSF) analysis were suggestive for encephalitis. Further laboratory examination revealed a serum MOG antibody titre. The headache improved with analgetic treatment and i.v. methylprednisolone. Consequently, the MOG antibody titer decreased and MRI lesions were resolving. The patient made a full recovery, with no signs of deterioration over the following months.

conclusionsCovid-19 manifestations in the CNS include encephalitis with variable course and prognosis. This case highlights a possible association between inflammation due to COVID-19 and transient secondary autoimmunity with transient MOG antibodies and atypical clinical presentation.

Indexed as

COVID-19EncephalitisAdultAntibodiesHumansMaleMyelin-Oligodendrocyte GlycoproteinSARS-CoV-2Young AdultAntibodiesMyelin-Oligodendrocyte GlycoproteinCOVID-19EncephalitisMethylprednisoloneMOG antibodyNeuropsychologySARS-CoV-2

Identifiers

PMID34706651
PMCPMC8549422
OpenAlexW3209408078

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.