Evidence map›Paper›PMID 34706639›Full record

ArticleBMC genomics2021

Identification of sheep lncRNAs related to the immune response to vaccines and aluminium adjuvants.

Martin Bilbao-Arribas, Endika Varela-Martínez, Naiara Abendaño, Damián de Andrés, Lluís Luján, Begoña M Jugo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Martin Bilbao-ArribasDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Endika Varela-MartínezDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Naiara AbendañoDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Damián de AndrésAnimal Health Department, Institute of Agrobiotechnology (IdAB, CSIC-Government of Navarra), Navarra, Spain.
Lluís LujánDepartment of Animal Pathology, Instituto Universitario de Investigación Mixto Agroalimentario de Aragón (IA2), University of Zaragoza, Zaragoza, Spain.
Begoña M JugoDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain. begonamarina.jugo@ehu.eus.
University of the Basque Country · ESAgrobiotechnology Institute · ESUniversidad de Zaragoza · ES

Funding

Spanish Ministry of Economy and Industry AGL2013-49137-C3University of the Basque Country (UPV/EHU) ESP-DOC 16/43University of the Basque Country (UPV/EHU) PIF15/361University of the Basque Country (UPV/EHU) PIF17/306
6 · The paper itself

Abstract

backgroundLong non-coding RNAs (lncRNAs) are involved in several immune processes, including the immune response to vaccination, but most of them remain uncharacterised in livestock species. The mechanism of action of aluminium adjuvants as vaccine components is neither not fully understood.

resultsWe built a transcriptome from sheep PBMCs RNA-seq data in order to identify unannotated lncRNAs and analysed their expression patterns along protein coding genes. We found 2284 novel lncRNAs and assessed their conservation in terms of sequence and synteny. Differential expression analysis performed between animals inoculated with commercial vaccines or aluminium adjuvant alone and the co-expression analysis revealed lncRNAs related to the immune response to vaccines and adjuvants. A group of co-expressed genes enriched in cytokine signalling and production highlighted the differences between different treatments. A number of differentially expressed lncRNAs were correlated with a divergently located protein-coding gene, such as the OSM cytokine. Other lncRNAs were predicted to act as sponges of miRNAs involved in immune response regulation.

conclusionsThis work enlarges the lncRNA catalogue in sheep and puts an accent on their involvement in the immune response to repetitive vaccination, providing a basis for further characterisation of the non-coding sheep transcriptome within different immune cells.

Indexed as

RNA, Long NoncodingVaccinesAluminumAnimalsGene Expression ProfilingImmunitySheepTranscriptomeAluminumRNA, Long NoncodingVaccinesAdjuvantsAluminiumCo-expressionImmune responseLncRNAsOvis ariesRNA-seqSystems biologyVaccine

Identifiers

PMID34706639
PMCPMC8554944
OpenAlexW3208442491

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.