ArticleArteriosclerosis, thrombosis, and vascular biology2021
Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Article
- Smartphone Measurement of Aortic Arch Pulse-Wave Velocity and Total Arterial Compliance: Accessible Local and Global Arterial Stiffness Assessment.Journal of the American Heart Association · 2026Observational
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Association Between Pulse Wave Velocity and Cerebral Small Vessel Disease: A Scoping Review.Cureus · 2025Review
- Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.Signal transduction and targeted therapy · 2025Review
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes.Frontiers in aging neuroscience · 2025Article
- Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.Frontiers in physiology · 2025Review
- Association of Arterial Stiffness Index and Brain Structure in the UK Biobank: A 10-Year Retrospective Analysis.Aging and disease · 2024Article
- Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclincal models.American journal of physiology. Heart and circulatory physiology · 2024Review
- Aortic Characteristic Impedance and Suspected Mild Cognitive Impairment in a Community-Based Healthy Population.Journal of the American Heart Association · 2024Article
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The association between kidney function, cognitive function, and structural brain abnormalities in community-dwelling individuals aged 50+ is mediated by age and biomarkers of cardiovascular disease.Cardiovascular research · 2023Article
- Cardiovascular profiles associated with white matter hyperintensities in healthy young women.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether baseline aortic stiffness, measured by aortic pulse wave velocity (PWV), relates to longitudinal cerebral gray or white matter changes among older adults. Baseline cardiac magnetic resonance imaging will be used to assess aortic PWV while brain magnetic resonance imaging will be used to assess gray matter and white matter hyperintensity (WMH) volumes at baseline, 18 months, 3 years, 5 years, and 7 years. Approach and Results: Aortic PWV (m/s) was quantified from cardiac magnetic resonance. Multimodal 3T brain magnetic resonance imaging included
conclusionsIn older adults, higher baseline aortic PWV related to greater decrease in gray matter volume and greater increase in WMHs over time. Because of unmet cerebral metabolic demands and microvascular remodeling, arterial stiffening may preferentially affect certain highly active brain regions like the temporal lobes. These same regions are affected early in the course of Alzheimer disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.