Evidence map›Paper›PMID 34706272›Full record

ArticleCell reports2021

Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation.

Anil Verma, Chase E Hawes, Yashavanth Shaan Lakshmanappa, Jamin W Roh, Brian A Schmidt, Joseph Dutra, William Louie, Hongwei Liu, Zhong-Min Ma, Jennifer K Watanabe and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Article
  6. Review
  7. COVID-19 therapeutics.Clinical microbiology reviews · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Anil VermaCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
Chase E HawesCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California, Davis, Davis, CA 95616, USA.
Yashavanth Shaan LakshmanappaCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
Jamin W RohCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California, Davis, Davis, CA 95616, USA.
Brian A SchmidtCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
Joseph DutraCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
William LouieDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Hongwei LiuDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Zhong-Min MaCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Jennifer K WatanabeCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Jodie L UsachenkoCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Ramya ImmareddyCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Rebecca L SammakCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
Rachel PollardCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
J Rachel ReaderCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Katherine J OlstadCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Lark L CoffeyDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Pamela A KozlowskiDepartment of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Dennis J Hartigan-O'ConnorCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Michel NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Koen K A Van RompayCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
John H MorrisonCalifornia National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Neurology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
Smita S IyerCenter for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: smiyer@ucdavis.edu.
University of California, Davis · USLouisiana State University Health Sciences Center New Orleans · USRockefeller University · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Investigating the Role of T cells in Age-related Neurodegeneration in HIV InfectionRF1AG061001 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA, MORRISON, JOHN H · 2018 to 2022
$5.0M
Role of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibilityR21AI143454 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2019 to 2020
$623k
NIAID NIH HHS R21 AI143454NIA NIH HHS RF1 AG061001NIH HHS P51 OD011107
6 · The paper itself

Abstract

Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.

Indexed as

AgingAnimalsAntibodies, MonoclonalCOVID-19Diabetes ComplicationsDiabetes Mellitus, ExperimentalFemaleHumansLymphocyte ActivationMacaca mulattaMaleNeuritisPre-Exposure ProphylaxisSARS-CoV-2T-LymphocytesVirus ReplicationAntibodies, Monoclonalcerebrospinal fluideffector CD4 T cellsinterstitial pneumonialymph nodeNeuroCOVID, inflammationneuroinflammationpathogenesisrhesus macaquesSARS-CoV-2

Identifiers

PMID34706272
PMCPMC8523485
OpenAlexW3205223712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.