Evidence map›Paper›PMID 34706258›Full record

ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2022

Noninvasive tests for eosinophilic esophagitis: Ready for use?

Emily C McGowan, Seema S Aceves

Open access · greenAbstract readReview
In one paragraph

Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Economic burden of eosinophilic esophagitis in the first year after diagnosis in Spain: A direct medical cost analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Observational
  4. Review
  5. Review
  6. A clinical predictive model identifies pediatric patients at risk for eosinophilic esophagitis.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2024
    Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Emily C McGowanDivision of Allergy and Immunology, University of Virginia School of Medicine, Charlottesville, Virginia; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: ekc5v@virginia.edu.
Seema S AcevesDivision of Allergy and Immunology, Departments of Pediatrics and Medicine, University of California San Diego, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
Johns Hopkins University · USRady Children's Hospital-San Diego · US

Funding

TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodelingR01DK114457 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Seema S Aceves, Ferhat Ay · 2018 to 2026
$4.5M
Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitisR01AI092135 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2011 to 2020
$4.4M
Mentoring Patient Oriented Research in Allergic Eosinophilic Gastrointestinal DisordersK24AI135034 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2018 to 2022
$898k
Dietary Methyl Donors and Food Allergy Risk in the United StatesK23AI123596 · NIAID · UNIVERSITY OF VIRGINIA · PI MCGOWAN, EMILY CLARKE · 2017 to 2020
$767k
IgE-Independent Mast Cell Activation by Food-Derived Peptides in Eosinophilic Esophagitis (EoE)R21AI151497 · NIAID · UNIVERSITY OF VIRGINIA · PI MCGOWAN, EMILY CLARKE · 2020 to 2021
$444k
Probing the Mechanisms of Fibroblast-Extracellular Matrix Interactions to Assess Disease Severity in Allergic Eosinophilic EsophagitisR21AI154353 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACEVES, SEEMA S · 2020 to 2021
$434k
NIAID NIH HHS K23 AI123596NIAID NIH HHS K24 AI135034NIAID NIH HHS R01 AI092135NIAID NIH HHS R21 AI151497NIAID NIH HHS R21 AI154353NIDDK NIH HHS R01 DK114457
6 · The paper itself

Abstract

objectiveTo summarize the existing literature for several promising minimally invasive tests to measure disease activity in eosinophilic esophagitis (EoE). DATA SOURCES: Literature searches were performed using PubMed. Keyword combinations included eosinophilic esophagitis and minimally invasive techniques, including the esophageal string test, Cytosponge, transnasal endoscopy, technetium-labeled heparin, and noninvasive biomarkers. STUDY SELECTIONS: Retrospective and prospective observational studies, peer-reviewed reviews, and systematic reviews were selected. Data were reviewed and summarized.

resultsVarious techniques have been developed in recent years to measure disease activity in EoE without the need for conventional endoscopy. Our review summarizes the data on these techniques, the benefits and limitations, and future directions for implementation in both research and clinical care.

conclusionTremendous progress has been made toward developing minimally invasive techniques to measure disease activity in EoE. Each of the techniques mentioned in this review has advantages and disadvantages, and some are closer to widespread use than others.

Indexed as

Eosinophilic EsophagitisBiomarkersHumansObservational Studies as TopicProspective StudiesRetrospective StudiesBiomarkers

Identifiers

PMID34706258
PMCPMC9035192
OpenAlexW3210795421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.