Evidence map›Paper›PMID 34706247›Full record

ArticleCell reports2021

Repression precedes independent evolutionary gains of a highly specific gene expression pattern.

Jian Pu, Zinan Wang, Haosu Cong, Jacqueline S R Chin, Jessa Justen, Cédric Finet, Joanne Y Yew, Henry Chung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jian PuDepartment of Entomology, Michigan State University, East Lansing, MI 48824, USA. Electronic address: pujian@msu.edu.
Zinan WangDepartment of Entomology, Michigan State University, East Lansing, MI 48824, USA; Ecology, Evolution, and Behavior Program, Michigan State University, East Lansing, MI 48824, USA.
Haosu CongDepartment of Entomology, Michigan State University, East Lansing, MI 48824, USA.
Jacqueline S R ChinSingapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A(∗)STAR), Brenner Centre for Molecular Medicine, Singapore 117609, Singapore.
Jessa JustenLaboratory of Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA.
Cédric FinetYale-NUS College, 16 College Avenue West, Singapore 138527, Singapore.
Joanne Y YewPacific Biosciences Research Center, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Henry ChungDepartment of Entomology, Michigan State University, East Lansing, MI 48824, USA; Ecology, Evolution, and Behavior Program, Michigan State University, East Lansing, MI 48824, USA. Electronic address: hwchung@msu.edu.
Michigan State University · USAgency for Science, Technology and Research · SGUniversity of Hawaiʻi at Mānoa · USUniversity of Wisconsin–Madison · USYale-NUS College · SG

Funding

The Control of Insect Metabolism through Nutrition-based SymbiosisP20GM125508 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Anthony Amend · 2018 to 2026
$21.2M
NIGMS NIH HHS P20 GM125508
6 · The paper itself

Abstract

Highly specific expression patterns can be caused by the overlapping activities of activator and repressor sequences in enhancers. However, few studies illuminate how these sequences evolve in the origin of new enhancers. Here, we show that expression of the bond gene in the semicircular wall epithelium (swe) of the Drosophila melanogaster male ejaculatory bulb (EB) is controlled by an enhancer consisting of an activator region that requires Abdominal-B driving expression in the entire EB and a repressor region that restricts this expression to the EB swe. Although this expression pattern is independently gained in the distantly related Scaptodrosophila lebanonensis and does not require Abdominal-B, we show that functionally similar repressor sequences are present in Scaptodrosophila and also in species that do not express bond in the EB. We suggest that during enhancer evolution, repressor sequences can precede the evolution of activator sequences and may lead to similar but independently evolved expression patterns.

Indexed as

AcetyltransferasesDrosophila ProteinsEnhancer Elements, GeneticEvolution, MolecularGene Expression RegulationAnimalsDrosophila melanogasterMaleSpecies SpecificityAcetyltransferasesbond protein, DrosophilaDrosophila ProteinsAbd-Bactivatorcis-regulatory evolutionenhancerfatty acyl-CoA elongaserepressor

Identifiers

PMID34706247
PMCPMC8578697
OpenAlexW3208125806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.