ArticleCell reports2021
fMRI neurofeedback in the motor system elicits bidirectional changes in activity and in white matter structure in the adult human brain.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Trial
- Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.Psychotherapy and psychosomatics · 2023Trial
- Self-modulation of motor cortex activity after stroke: a randomized controlled trial.Brain : a journal of neurology · 2022Trial
- Long-term outcomes and age-dependent recovery trajectories following short-term spinal cord stimulation in patients with disorders of consciousness.Frontiers in neurology · 2026Article
- Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics.Journal of neuroengineering and rehabilitation · 2025Review
- Linking neuron-axon-synapse architecture to white matter vasculature using high-resolution multimodal MRI in primate brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Real-time fMRI neurofeedback boosts heartbeat perception by modulating insula activation pattern during interoceptive attention.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Closed-loop fMRI at the mesoscopic scale of columns and layers: Can we do it and why would we want to?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Effects of one session of theta or high alpha neurofeedback on EEG activity and working memory.Cognitive, affective & behavioral neuroscience · 2024Article
- Immediate effect of quadri-pulse stimulation on human brain microstructures and functions.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback.Journal of electrical bioimpedance · 2024Article
- Preliminary findings on long-term effects of fMRI neurofeedback training on functional networks involved in sustained attention.Brain and behavior · 2023Article
- Neurological Mechanisms of Diagnosis and Therapy in School Children with ADHD in Poland.International journal of environmental research and public health · 2022Article
- Could Brain-Computer Interface Be a New Therapeutic Approach for Body Integrity Dysphoria?Frontiers in human neuroscience · 2021Review
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
White matter (WM) plasticity supports skill learning and memory. Up- and downregulation of brain activity in animal models lead to WM alterations. But can bidirectional brain-activity manipulation change WM structure in the adult human brain? We employ fMRI neurofeedback to endogenously and directionally modulate activity in the sensorimotor cortices. Diffusion tensor imaging is acquired before and after two separate conditions, involving regulating sensorimotor activity either up or down using real or sham neurofeedback (n = 20 participants × 4 scans). We report rapid opposing changes in corpus callosum microstructure that depend on the direction of activity modulation. Our findings show that fMRI neurofeedback can be used to endogenously and directionally alter not only brain-activity patterns but also WM pathways connecting the targeted brain areas. The level of associated brain activity in connected areas is therefore a possible mediator of previously described learning-related changes in WM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.