ArticleNeuron2021
Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.
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Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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31 citing papers in PubMed, 45 citations in OpenAlex.
- Nucleus Accumbens and Ventral Tegmental Area Functional Connectivity as a Marker of Reward Sensitivity in Infancy.Developmental science · 2026Article
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Autism-like behavior Increases with age and is predated by molecular changes in Arid1b haploinsufficient mice.Neuroscience · 2026Article
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Oxytocin signaling regulates maternally directed behavior during early life.Science (New York, N.Y.) · 2025Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala.The Journal of comparative neurology · 2025Article
- Building a social brain: Cells, circuits and behavior across the lifespan.Neurobiology of stress · 2025Review
- Early-life stress sensitizes response to future stress: Evidence and mechanisms.Neurobiology of stress · 2025Review
- Understanding the development of a functional brain circuit: reward processing as an illustration.Translational psychiatry · 2025Review
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- Neurons for infant social behaviors in the mouse zona incerta.Science (New York, N.Y.) · 2024Article
- Anxious about rejection, avoidant of neglect: Infant marmosets tune their attachment based on individual caregiver's parenting style.Communications biology · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Neural Circuit Transitions Supporting Developmentally Specific Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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Authors and funding
18 authors at 6 institutions in 1 country.
Maya OpendakDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Kennedy Krieger Institute, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: opendak@kennedykrieger.org.
Charlis RainekiDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Psychology, Brock University, St. Catharines, ON L2S 3A1, Canada.
Rosemarie E PerryDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Applied Psychology, New York University, New York, NY 10012, USA.
Millie Rincón-CortésDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Neuroscience, University of Pittsburgh, Pittsburgh PA 15260, USA.
Soomin C SongSkirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA; Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Roseanna M ZancaDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Department of Psychology, CUNY Hunter College, New York, 10016, USA; The Graduate Center of CUNY, New York, 10016, USA.
Emma WoodDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Katherine PackardDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Shannon HuDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Joyce WooDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Krissian MartinezDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA.
K Yaragudri VinodDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Russell W BrownDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
Gerald A DeehanDepartment of Psychology, East Tennessee State University, Johnson City, TN 37614, USA.
Robert C FroemkeCenter for Neural Science, New York University, New York, NY 10003, USA; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA; Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Otolaryngology, New York University School of Medicine, New York, NY 10016, USA; Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.
Peter A SerranoDepartment of Psychology, CUNY Hunter College, New York, 10016, USA; The Graduate Center of CUNY, New York, 10016, USA.
Donald A WilsonDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Regina M SullivanDepartment of Child and Adolescent Psychiatry, NYU Langone Health, New York, NY 10016, USA; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: regina.sullivan@nyulangone.org.
Nathan Kline Institute for Psychiatric Research · USEast Tennessee State University · USNew York University · USThe Graduate Center, CUNY · USKennedy Krieger Institute · USNYU Langone Health · US
Funding
RISE Program Hunter College Option IIIR25GM060665 · NIGMS · HUNTER COLLEGE · PI ORTIZ, BENJAMIN D.,, SERRANO, PETER A · 2000 to 2022
$22.8MNeural circuitry of oxytocin signaling for alloparenting behavior- Revision - 1R01HD088411 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Robert Crooks Froemke · 2017 to 2026
$5.2MMaternal Influence Over Prefrontal Cortex and Transition to Independence - Revision - 2R37HD083217 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SULLIVAN, REGINA MARIE · 2015 to 2024
$4.7MNeurobiology of Social Behavior: Circuit Analysis in Early LifeR00MH124434 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI OPENDAK, MAYA · 2022 to 2024
$961kNeurobiology of Social Behavior: Circuit Analysis in Early LifeK99MH124434 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OPENDAK, MAYA · 2020 to 2021
$209kIdentifying a role for the amygdala in social behavior deficits following early-life traumaF32MH112232 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OPENDAK, MAYA · 2016 to 2018
$116kNICHD NIH HHS R01 HD088411NICHD NIH HHS R37 HD083217NIGMS NIH HHS R25 GM060665NIMH NIH HHS F32 MH112232NIMH NIH HHS K99 MH124434NIMH NIH HHS R00 MH124434
Abstract
Social interaction deficits seen in psychiatric disorders emerge in early-life and are most closely linked to aberrant neural circuit function. Due to technical limitations, we have limited understanding of how typical versus pathological social behavior circuits develop. Using a suite of invasive procedures in awake, behaving infant rats, including optogenetics, microdialysis, and microinfusions, we dissected the circuits controlling the gradual increase in social behavior deficits following two complementary procedures-naturalistic harsh maternal care and repeated shock alone or with an anesthetized mother. Whether the mother was the source of the adversity (naturalistic Scarcity-Adversity) or merely present during the adversity (repeated shock with mom), both conditions elevated basolateral amygdala (BLA) dopamine, which was necessary and sufficient in initiating social behavior pathology. This did not occur when pups experienced adversity alone. These data highlight the unique impact of social adversity as causal in producing mesolimbic dopamine circuit dysfunction and aberrant social behavior.
Indexed as
Basolateral Nuclear ComplexDopamineAmygdalaAnimalsHumansOptogeneticsRatsSocial BehaviorDopamineadversityamygdaladevelopmentdopamineparentingsocial behavior
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