Evidence map›Paper›PMID 34705599›Full record

ArticleRNA biology2021

Conditional depletion of transcriptional kinases Ctk1 and Bur1 and effects on co-transcriptional spliceosome assembly and pre-mRNA splicing.

Isabella E Maudlin, Jean D Beggs

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Isabella E MaudlinWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Jean D BeggsWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8179-6519
Wellcome Centre for Cell Biology · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

From yeast to humans, pre-mRNA splicing occurs mainly co-transcriptionally, with splicing and transcription functionally coupled such that they influence one another. The recruitment model of co-transcriptional splicing proposes that core members of the transcription elongation machinery have the potential to influence co-transcriptional spliceosome assembly and pre-mRNA splicing. Here, we tested whether the transcription elongation kinases Bur1 and Ctk1 affect co-transcriptional spliceosome assembly and pre-mRNA splicing in the budding yeast

Indexed as

Gene Expression Regulation, FungalRNA SplicingChromosomal Proteins, Non-HistoneCyclin-Dependent KinasesPhosphorylationProtein KinasesRNA PrecursorsSaccharomyces cerevisiae ProteinsSpliceosomesTranscriptional Elongation FactorsChromosomal Proteins, Non-HistoneCTDK-I protein complex, S cerevisiaeCyclin-Dependent KinasesProtein KinasesRNA PrecursorsSaccharomyces cerevisiae ProteinsSGV1 protein, S cerevisiaeSPT5 transcriptional elongation factorTranscriptional Elongation FactorsCTDpre-mRNA splicingserine 2 phosphorylationTranscription elongationyeast

Identifiers

PMID34705599
PMCPMC8782173
OpenAlexW3208806416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.