ArticleJournal of virology2022
Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.
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In one paragraph
Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Essential role of hsa-miR-203a-3p in type I interferons immune homeostasis during influenza and NDV infection.RNA biology · 2026Article
- Inhaled pattern recognition receptor agonists promote inducible epithelial resistance against murine betacoronavirus disease.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Deciphering interferon functions in avian influenza using receptor knockout models in the natural host.eLife · 2026Article
- Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.Physiological reports · 2025Article
- Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors.Nature communications · 2024Article
- Context-specific anti-inflammatory roles of type III interferon signaling in the lung in nonviral injuries.Physiological reports · 2024Article
- IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN.JCI insight · 2024Article
- Review
- Article
- COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes.Communications biology · 2023Article
- Review
- Interferons in COVID-19: missed opportunities to prove efficacy in clinical phase III trials?Frontiers in medicine · 2023Article
- Airways tissue expression of type I interferons and their stimulated genes is higher in children than adults.Heliyon · 2022Article
- Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Priming With Rhinovirus Protects Mice Against a Lethal Pulmonary Coronavirus Infection.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 2 institutions in 2 countries.
Lokesh Sharma *Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.ORCID 0000-0003-3040-9029
Xiaohua Peng *Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Hua Qing *Section of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Brandon K HilliardSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Jooyoung KimSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Anush SwaminathanSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Justin TianSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Kavita Israni-WingerSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Cuiling ZhangSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Victoria HabetSection of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Lin WangSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Gayatri GuptaSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Xuefei TianSection of Nephrology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Yina MaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Hyeon-Jun ShinSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Sang-Hun KimSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Min-Jong KangSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Shuta IshibeSection of Nephrology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Lawrence H YoungSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Sergei KotenkoDepartment of Biochemistry and Molecular Biology, Rutgers New Jersey Medical School, New Brunswick, New Jersey, USA.
Susan ComptonMolecular and Serological Diagnostics, Department of Comparative Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Craig B WilenDepartment of Immunobiology, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.ORCID 0000-0003-2495-9403
Andrew WangSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Charles S Dela CruzSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale School of Medicinegrid.471390.8, New Haven, Connecticut, USA.
Yale University · USRutgers, The State University of New Jersey · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5MTraining Translational Lung Biology and PathobiologyT32HL007778 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog, NAFTALI KAMINSKI · 1994 to 2026
$14.4MHost-Pneumococcal Interaction in the LungR01HL126094 · NHLBI · YALE UNIVERSITY · PI DELA CRUZ, CHARLES S · 2015 to 2019
$2.1MRegulation of Metabolic Programs for Host Tolerance to InflammationK08AI128745 · NIAID · YALE UNIVERSITY · PI WANG, ANDREW · 2017 to 2021
$784kMAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPDI01BX004661 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI DELA CRUZ, CHARLES S · 2020 to 2024
–American Lung Association (ALA)BLRD VA I01 BX004661Francis Family Foundation (FF)HHS | National Institutes of Health (NIH) 1K08AI128745NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL126094NHLBI NIH HHS T32 HL007778NIAID NIH HHS K08 AI128745NIGMS NIH HHS T32 GM136651Pew Charitable Trusts (Pew)U.S. Department of Defense (DOD)U.S. Department of Veterans Affairs (VA) BX004661
Abstract
Coronaviruses are a major health care threat to humankind. Currently, the host factors that contribute to limit disease severity in healthy young patients are not well defined. Interferons are key antiviral molecules, especially type I and type III interferons. The role of these interferons during coronavirus disease is a subject of debate. Here, using mice that are deficient in type I (IFNAR1
Indexed as
LungAnimalsCoronavirus InfectionsFemaleInterferon LambdaInterferonsInterferon Type IMaleMiceMice, Inbred C57BLMice, KnockoutInterferon LambdaInterferonsInterferon Type Iantiviral agentscoronaviruslung defensetype III interferonstype I interferons
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What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.