ArticleScience advances2021
Theta oscillations coordinate grid-like representations between ventromedial prefrontal and entorhinal cortex.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Olfactory-to-Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency-Specific Oscillatory Decoupling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Entorhinal grid-like codes for visual space during memory formation.Nature communications · 2025Article
- Sensorimotor Theta Oscillations Coordinate Speech Movements.bioRxiv : the preprint server for biology · 2025Article
- Coordinated hippocampal-entorhinal representations support human context-dependent spatial navigation.PLoS biology · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Sustained Hippocampal Theta Oscillations Reflect Experience-Dependent Learning in Backward Temporal Order Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia.eLife · 2024Article
- Article
- Differential effects of allopregnanolone and diazepam on social behavior through modulation of neural oscillation dynamics in basolateral amygdala and medial prefrontal cortex.Frontiers in cellular neuroscience · 2024Article
- Entorhinal grid-like codes and time-locked network dynamics track others navigating through space.Nature communications · 2023Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grid cells and theta oscillations are fundamental constituents of the brain’s navigation system and have been described in the entorhinal cortex (EC). Recent fMRI studies reveal that the ventromedial prefrontal cortex (vmPFC) contains grid-like representations. However, the neural mechanisms underlying human vmPFC grid-like representations and their interactions with EC grid activity have remained unknown. We conducted intracranial electroencephalography (iEEG) recordings from epilepsy patients during a virtual spatial navigation task. Oscillatory theta power in the vmPFC exhibited a sixfold rotational symmetry that was coordinated with grid-like representations in the EC. We found that synchronous theta oscillations occurred between these regions that predicted navigational performance. Analysis of information transfer revealed a unidirectional signal from vmPFC to EC during memory retrieval. Together, this study provides insights into the previously unknown neural signature and functional role of grid-like representations outside the EC and their synchronization with the entorhinal grid during human spatial navigation.
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Registered trials
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