Evidence map›Paper›PMID 34705503›Full record

ArticleScience advances2021

Ryanodine receptor leak triggers fiber Ca

Cedric R Lamboley, Luke Pearce, Crystal Seng, Aldo Meizoso-Huesca, Daniel P Singh, Barnaby P Frankish, Vikas Kaura, Harriet P Lo, Charles Ferguson, Paul D Allen and 6 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. iPLAScience advances · 2026
    Article
  3. Ryanodine Receptor CaActa physiologica (Oxford, England) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Phosphorylation of RYR1 at SerScience signaling · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Targeting mitochondrial CaThe Journal of physiology · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Cedric R LamboleySchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-4008-4929
Luke PearceSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Crystal SengSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-2106-5826
Aldo Meizoso-HuescaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-7873-5398
Daniel P SinghSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-4868-2501
Barnaby P FrankishDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0003-0694-4670
Vikas KauraLeeds Institute of Medical Research, University of Leeds, Leeds, UK.ORCID 0000-0002-8984-9662
Harriet P LoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Charles FergusonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Paul D AllenLeeds Institute of Medical Research, University of Leeds, Leeds, UK.
Philip M HopkinsLeeds Institute of Medical Research, University of Leeds, Leeds, UK.ORCID 0000-0002-8127-1739
Robert G PartonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0002-7494-5248
Robyn M MurphyDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0003-3697-589X
Chris van der PoelDepartment of Physiology Anatomy and Microbiology, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0002-8750-3641
Christopher J BarclaySchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-0903-3111
Bradley S LaunikonisSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-0700-4867
The University of Queensland · AULa Trobe University · AUUniversity of Leeds · GB

Funding

Mechanisms controlling Ca2+ dyshomeostasis in MH susceptible miceR01AR068897 · NIAMS · UNIVERSITY OF LEEDS · PI ALLEN, PAUL D · 2016 to 2020
$1.2M
NIAMS NIH HHS R01 AR068897
6 · The paper itself

Abstract

Muscle contraction depends on tightly regulated Ca

Identifiers

PMID34705503
PMCPMC8550231
OpenAlexW3211105620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.