Evidence map›Paper›PMID 34705493›Full record

ArticleMolecular biology of the cell2022

The microtubule- and PP1-binding activities of

Margaux R Audett, Erin L Johnson, Jessica M McGory, Dylan M Barcelos, Evelin Oroszne Szalai, Marcin R Przewloka, Thomas J Maresca

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Margaux R AudettBiology Department, University of Massachusetts, Amherst, Amherst MA 01003.
Erin L JohnsonBiology Department, University of Massachusetts, Amherst, Amherst MA 01003.
Jessica M McGoryBiology Department, University of Massachusetts, Amherst, Amherst MA 01003.
Dylan M BarcelosBiology Department, University of Massachusetts, Amherst, Amherst MA 01003.
Evelin Oroszne SzalaiInstitute for Life Sciences, School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Marcin R PrzewlokaInstitute for Life Sciences, School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Thomas J MarescaBiology Department, University of Massachusetts, Amherst, Amherst MA 01003.
University of Massachusetts Amherst · USUniversity of Southampton · GB

Funding

Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Mechano-molecular regulation of kinetochore functionR01GM107026 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MARESCA, THOMAS JOSEPH · 2013 to 2022
$2.7M
Cellular Engineering Biotechnology Training ProgramT32GM108556 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HARDY, JEANNE ANN, PEYTON, SHELLY R. · 2015 to 2019
$766k
NIGMS NIH HHS R01 GM107026NIGMS NIH HHS T32 GM108556NIGMS NIH HHS T32 GM135096Wellcome TrustWellcome Trust 208908/Z/17/Z
6 · The paper itself

Abstract

KNL1 is a large intrinsically disordered kinetochore (KT) protein that recruits spindle assembly checkpoint (SAC) components to mediate SAC signaling. The N-terminal region (NTR) of KNL1 possesses two activities that have been implicated in SAC silencing: microtubule (MT) binding and protein phosphatase 1 (PP1) recruitment. The NTR of

Indexed as

AnimalsAurora Kinase BCell Cycle CheckpointsCell Cycle ProteinsChromosome SegregationDrosophila melanogasterDrosophila ProteinsKineticsKinetochoresMicrotubule-Associated ProteinsMicrotubulesM Phase Cell Cycle CheckpointsProtein BindingProtein Phosphatase 1Receptors, Neuropeptide YSpindle ApparatusAurora Kinase BCell Cycle ProteinsDrosophila ProteinsMicrotubule-Associated ProteinsProtein Phosphatase 1Receptors, Neuropeptide YSpc105R protein, Drosophila

Identifiers

PMID34705493
PMCPMC8886820
OpenAlexW3209531080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.