Evidence map›Paper›PMID 34705229›Full record

ArticleMolecular neurobiology2022

SNARE Proteins Mediate α-Synuclein Secretion via Multiple Vesicular Pathways.

Xiaofang Zhao, Yuan Guan, Fengwei Liu, Shuxin Yan, Yalong Wang, Meiqin Hu, Yuhong Li, Rena Li, Claire Xi Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Xiaofang ZhaoBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Yuan GuanBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Fengwei LiuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Shuxin YanBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Yalong WangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Meiqin HuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, 48105, USA.
Yuhong LiBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China.
Rena LiBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China. renali@ccmu.edu.cn.
Claire Xi ZhangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, 100069, China. Xi.Zhang@xjtlu.edu.cn.ORCID http://orcid.org/0000-0002-4687-039X
Capital Medical University · CNMinistry of Science and Technology · VNUniversity of Michigan · US

Funding

Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education KZ201510025023Chaoyang District Science and Technology Plan Project CYSF-1933National Natural Science Foundation of China 31471085National Natural Science Foundation of China 81671248National Natural Science Foundation of China 91849103
6 · The paper itself

Abstract

The cell-to-cell transmission of pathological α-synuclein (α-syn) has been proposed to be a critical event in the development of synucleinopathies. Recent studies have begun to reveal the underlying molecular mechanism of α-syn propagation. As one of the central steps, α-syn secretion is reported to be Ca

Indexed as

alpha-SynucleinAnimalsAutophagosomesCell Line, TumorEndosomesExocytosisHumansLysosomesNeuronsRatsRats, Sprague-DawleySNARE ProteinsVesicular Transport Proteinsalpha-SynucleinSNARE ProteinsVesicular Transport ProteinsAutophagosomeEndosomeExocytosisLysosomeSNAREα-Synuclein

Identifiers

PMID34705229
OpenAlexW3208917632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.