Evidence map›Paper›PMID 34705218›Full record

ArticleMolecular biology reports2022

Estrogen-induced downregulation of TASK-1 expression through estrogen receptor β in N2A cells.

Xiao-Yue Qiu, Xian-Tao Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiao-Yue QiuDepartment of Neuroscience, South-Central University for Nationalities, 182 Minyuan Road, Wuhan, 430074, China.
Xian-Tao LiDepartment of Neuroscience, South-Central University for Nationalities, 182 Minyuan Road, Wuhan, 430074, China. lix3579@hotmail.com.ORCID http://orcid.org/0000-0002-0093-620X
South Central Minzu University · CN

Funding

Research project of SCUN HZY18032
6 · The paper itself

Abstract

backgroundOur previous data revealed that reduction of TASK-1 expression, as a consequence of exposure to 17β-estradiol, could participate in neuroprotective effects in N2A cells. However, it is unclear which estrogen receptor underlies these effects of 17β-estradiol. METHODS AND

resultsIn this study, the knockdown experiments are carried out to clarify the estrogen receptor responsible for effects of estrogen on TASK-1 channels. Subsequently, data from QPCR measurements reveal that estrogen receptor β (ERβ), but not estrogen receptor α, serves as a binding target for 17β-estradiol after a 48-h treatment.

conclusionsThe current result suggests the implication of the ERβ-dependent manner in the pro-proliferative action of estrogen via TASK-1 channels.

Indexed as

AnimalsCell LineCell ProliferationDown-RegulationEstradiolEstrogen Receptor alphaEstrogen Receptor betaEstrogensGene Knockdown TechniquesMiceNerve Tissue ProteinsNeural CrestNeuroprotective AgentsPolymerase Chain ReactionPotassium Channels, Tandem Pore DomainRNA InterferenceEstradiolEstrogen Receptor alphaEstrogen Receptor betaEstrogensNerve Tissue ProteinsNeuroprotective AgentsPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3RNA, MessengerEstrogenEstrogen receptorN2A cellsTASK-1 channels

Identifiers

PMID34705218
OpenAlexW3209895153

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.