Evidence map›Paper›PMID 34705173›Full record

ArticleBulletin of experimental biology and medicine2021

Functioning of the Antioxidant Defense System in Rotenone-Induced Parkinson's Disease.

E D Kryl'skii, G A Razuvaev, T N Potapova, A I Akinina, L E Nihaev

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

E D Kryl'skiiDepartment of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia. evgenij.krylsky@yandex.ru.
G A RazuvaevDepartment of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
T N PotapovaDepartment of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
A I AkininaDepartment of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
L E NihaevDepartment of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
Voronezh State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.

Indexed as

AnimalsAntioxidantsBrainCatalaseGene ExpressionGlutathioneGlutathione PeroxidaseGlutathione ReductaseGlutathione TransferaseMaleMitochondriaOxidative StressParkinson Disease, SecondaryRatsRats, WistarRotenoneAntioxidantsCatalaseGlutathioneGlutathione PeroxidaseGlutathione ReductaseGlutathione TransferaseRotenoneSuperoxide Dismutaseantioxidant systemoxidative stressParkinson’s diseaserotenone

Identifiers

PMID34705173
OpenAlexW3174735233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.