The Effect of TLR Agonists and Myokines on Secretory Activity of Adipogenically Differentiated MSC Cultures.

A V Shestopalov, A Mishra, A M Gaponov, S A Rumyantsev

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A V ShestopalovN. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.

A MishraMoscow Institute of Physics and Technology (National Research University), Dolgoprudny, Moscow region, Russia. mishra@phystech.edu.

A M GaponovCenter of Digital and Translational Biomedicine, LLC "Center for Molecular Health", Moscow, Russia.

S A RumyantsevN. I. Pirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.

Pirogov Russian National Research Medical University · RUMoscow Power Engineering Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of bacterial pathogen-associated molecular patterns and myokines on the secretion of adipokines by mesenchymal stem cells (MSC) and products of their adipogenic differentiation. The secretion of adiponectin, adipsin, leptin, and insulin by adipogenically differentiated cell cultures was quantitatively determined using multiplex ELISA. MSC obtained from the stromal vascular fraction of human subcutaneous adipose tissue were shown to secrete a known adipokine adipsin. The ability of white adipocytes to secrete significant amounts of insulin (in vitro) has been shown for the first time. Control cultures of white adipocytes secreted much higher levels of adiponectin, leptin, and insulin when compared to other adipocytes cultures. On the other hand, beige and brown adipocyte cultures secreted more adipsin than white adipocyte cultures. The influence of myokine β-aminoisobutyric acid on the secretion of adipsin in MSC, white, beige, and brown adipocytes was also studied.

Indexed as

Adipocytes, BeigeAdipocytes, BrownAdipocytes, WhiteAdipogenesisAdipokinesAdiponectinAdipose Tissue, BrownAminoisobutyric AcidsCell DifferentiationComplement Factor DFlagellinGene Expression RegulationHumansInsulinLeptinLipectomy3-aminoisobutyric acidAdipokinesAdiponectinADIPOQ protein, humanAminoisobutyric AcidsCFD protein, humanComplement Factor DFlagellinInsulinLEP protein, humanLeptinLipopolysaccharidesMetrnl protein, humanadipocytesadipokinesinsulinLPSmesenchymal stem cells

Identifiers

PMID34705171

DOI10.1016/j.tem.2015.03.002

OpenAlexW3175783437

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.