Evidence map›Paper›PMID 34704856›Full record

ArticlePhysiology (Bethesda, Md.)2021

Physics and Physiology of Cell Spreading in Two and Three Dimensions.

Paul A Janmey, Boris Hinz, Christopher A McCulloch

Abstract read
In one paragraph

Article in Physiology (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Considerations and implications of currentFrontiers in cell and developmental biology · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Tissue Morphogenesis Through Dynamic Cell and Matrix Interactions.Annual review of cell and developmental biology · 2023
    Review
  12. Article
  13. Article
  14. Impact of Vimentin on Regulation of Cell Signaling and Matrix Remodeling.Frontiers in cell and developmental biology · 2022
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paul A JanmeyInstitute for Medicine and Engineering, Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-3495-3286
Boris HinzFaculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Christopher A McCullochFaculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Funding

Pathological consequences of altered tissue mechanics in fibrosisR01EB017753 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI JANMEY, PAUL A, SHENOY, VIVEK · 2014 to 2025
$6.3M
Regulation of cell, tissue, and nucleus function by mechanical properties of biopolymer networksR35GM136259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Paul A Janmey · 2020 to 2026
$3.2M
Integration of elasticity, viscosity, and plasticity in cellular mechanosensingR01EB030876 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SHENOY, VIVEK · 2020 to 2023
$1.3M
NIBIB NIH HHS R01 EB017753NIBIB NIH HHS R01 EB030876NIGMS NIH HHS R35 GM136259
6 · The paper itself

Abstract

Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide, and move. Both chemical and physical signals orchestrate spreading during normal development, wound healing, and pathological states such as fibrosis and tumor growth. Diverse molecular mechanisms drive different forms of cell spreading. This article discusses mechanisms by which cells spread in 2-D and 3-D and illustrates new directions in studies of this aspect of cell function.

Indexed as

PhysicsCell AdhesionCell Movementactinfibrosisfocal adhesionthermal ratchet

Identifiers

PMID34704856
PMCPMC8560373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.