Evidence map›Paper›PMID 34704845›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis.

Ellen P S Conceição Furber, Clarissa M D Mota, Edward Veytsman, Shaun F Morrison, Christopher J Madden

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine".International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ellen P S Conceição FurberDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.
Clarissa M D MotaDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0001-7113-6173
Edward VeytsmanDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.
Shaun F MorrisonDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.
Christopher J MaddenDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon.ORCID 0000-0001-6949-5695
Oregon Health & Science University · US

Funding

Neural mechanisms in high fat diet impairment of brown adipose tissue activityR01DK112198 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MADDEN, CHRISTOPHER J · 2018 to 2022
$2.1M
NIDDK NIH HHS R01 DK112198
6 · The paper itself

Abstract

Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. However, the central thermoregulatory pathways modulated by DA have not been fully elucidated. Here we identified a source and site of action contributing to DA's hypothermic action by inhibition of brown adipose tissue (BAT) thermogenesis. Nanoinjection of the type 2 and type 3 DA receptor (D2R/D3R) agonist, 7-hydroxy-

Indexed as

Neural InhibitionThermogenesisAdipose Tissue, BrownAnimalsDopamineDopamine AgonistsDopaminergic NeuronsGABA AntagonistsHypothalamus, PosteriorInjectionsMaleNeural PathwaysNucleus Raphe PallidusRatsRats, Sprague-DawleyReceptors, Dopamine D2DopamineDopamine AgonistsDrd3 protein, ratGABA AntagonistsReceptors, Dopamine D2Receptors, Dopamine D3Receptors, GABA-AReceptors, N-Methyl-D-Aspartate7-OH-DPATSB-277011Athermoregulation

Identifiers

PMID34704845
PMCPMC8714813
OpenAlexW3209564872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.