Evidence map›Paper›PMID 34704827›Full record

ArticleMicrobiology spectrum2021

Hypochlorous Acid-Generating Electrochemical Catheter Prototype for Prevention of Intraluminal Infection.

Edison J Cano, Laure Flurin, Abdelrhman Mohamed, Kerryl E Greenwood-Quaintance, Yash S Raval, Haluk Beyenal, Robin Patel

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. A Novel BODIPY-Dinitrophenylhydrazine "Off-On" Hypochlorite Ion Fluorescent Probe Based on ICT Mechanism.Luminescence : the journal of biological and chemical luminescence · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. HOCl-producing electrochemical bandage for treatingAntimicrobial agents and chemotherapy · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Edison J Cano *Division of Infectious Diseases, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0002-0154-2544
Laure Flurin *Division of Clinical Microbiology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0001-5687-1081
Abdelrhman MohamedThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State Universitygrid.30064.31, Pullman, Washington, USA.ORCID 0000-0003-2132-0487
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Yash S RavalDivision of Clinical Microbiology, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0003-1161-4000
Haluk BeyenalThe Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State Universitygrid.30064.31, Pullman, Washington, USA.
Robin PatelDivision of Infectious Diseases, Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0001-6344-4141
Mayo Clinic · USWashington State University · US

Funding

The Electricidal Effect, a Novel Anti-Biofilm StrategyR01AI091594 · NIAID · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2011 to 2026
$5.5M
Electrochemical Catheter for Prevention of Central Line-Associated Bloodstream InfectionR01HL166238 · NHLBI · MAYO CLINIC ROCHESTER · PI Haluk Beyenal, Robin Patel · 2023 to 2026
$1.5M
NHLBI NIH HHS R01 HL166238NIAID NIH HHS R01 AI091594
6 · The paper itself

Abstract

Central line-associated bloodstream infection (CLABSI) contributes to mortality and cost. While aseptic dressings and antibiotic-impregnated catheters prevent some extraluminal infections, intraluminal infections remain a source of CLABSIs. In this proof-of-concept study, an electrochemical intravascular catheter (e-catheter) prototype capable of electrochemically generating hypochlorous acid intraluminally using platinum electrodes polarized at a constant potential of 1.5 electrode potential relative to saturated silver/silver chloride reference electrode measured in volts (V

Indexed as

CathetersAnti-Bacterial AgentsCatheter-Related InfectionsElectrochemical TechniquesEscherichia coliFemaleHumansHypochlorous AcidMaleStaphylococcal InfectionsAnti-Bacterial AgentsHypochlorous Acidcatheter-related bloodstream infectionelectrochemistryhypochlorous acidinfection prevention

Identifiers

PMID34704827
PMCPMC8549727
OpenAlexW3208992010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.