Evidence map›Paper›PMID 34704806›Full record

ArticleMicrobiology spectrum2021

Nonpathogenic Cutibacterium acnes Confers Host Resistance against Staphylococcus aureus.

Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Transcriptomic Profiling ofCurrent issues in molecular biology · 2025
    Article
  6. Article
  7. Article
  8. Microbe Interactions within the Skin Microbiome.Antibiotics (Basel, Switzerland) · 2024
    Review
  9. Bioscience of microbiota, food and health · 2024
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ayano TsuruGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.
Yumi HamazakiGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.
Shuta TomidaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan.
Mohammad Shaokat AliGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.
Tomomi KomuraGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.
Yoshikazu NishikawaGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.ORCID 0000-0001-9453-0739
Eriko Kage-NakadaiGraduate School of Human Life Science, Osaka City Universitygrid.261445.0, Osaka, Japan.ORCID 0000-0001-5068-0460
Osaka City University · JPOkayama University Hospital · JPTezukayama Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutibacterium acnes is a human skin-resident bacterium. Although C. acnes maintains skin health by inhibiting invasion from pathogens like Staphylococcus aureus, it also contributes to several diseases, including acne. Studies suggest that differences in genetic background may explain the diverse phenotypes of C. acnes strains. In this study, we investigated the effects of C. acnes strains on the Caenorhabditis elegans life span and observed that some strains shortened the life span, whereas other strains, such as strain HL110PA4, did not alter it. Next, we assessed the effects of C. acnes HL110PA4 on host resistance against S. aureus. The survival time of C. acnes HL110PA4-fed wild-type animals was significantly longer than that of Escherichia coli OP50 control bacterium-fed worms upon infection with S. aureus. Although the survival times of worms harboring mutations at the

Indexed as

Disease ResistanceStaphylococcal InfectionsStaphylococcus aureusAnimalsBacteriaCaenorhabditis elegansEcosystemEscherichia coliEscherichia coli InfectionsHost-Pathogen InteractionsHumansp38 Mitogen-Activated Protein KinasesSkinp38 Mitogen-Activated Protein KinasesCaenorhabditis elegansCutibacterium acnesp38 MAPKStaphylococcus aureustir-1

Identifiers

PMID34704806
PMCPMC8549750
OpenAlexW3208680365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.