Evidence map›Paper›PMID 34704803›Full record

ArticleMicrobiology spectrum2021

Deciphering the Role of Mucosal Immune Responses and the Cervicovaginal Microbiome in Resistance to HIV Infection in HIV-Exposed Seronegative (HESN) Women.

Sivasankaran Munusamy Ponnan, Kannan Thiruvengadam, Chaitanya Tellapragada, Anoop T Ambikan, Aswathy Narayanan, Sujitha Kathirvel, Manikannan Mathayan, Janani Shankar, Akshaya Rajaraman, Mehar Afshan Amanulla and 9 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. CXCR6Frontiers in immunology · 2026
    Article
  2. HIV-Exposed Seronegative Female Sex Workers Show Different Cellular Immune Profiles Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  3. Review
  4. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  5. Article
  6. Review
  7. Interactions between microbiota and cervical epithelial, immune, and mucus barrier.Frontiers in cellular and infection microbiology · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

Sivasankaran Munusamy PonnanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.ORCID 0000-0001-6705-4474
Kannan ThiruvengadamNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Chaitanya TellapragadaDivision of Clinical Microbiology, Karolinska Institutegrid.4714.6, Stockholm, Sweden.
Anoop T AmbikanDivision of Clinical Microbiology, Karolinska Institutegrid.4714.6, Stockholm, Sweden.
Aswathy NarayananDivision of Clinical Microbiology, Karolinska Institutegrid.4714.6, Stockholm, Sweden.
Sujitha KathirvelNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Manikannan MathayanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Janani ShankarNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Akshaya RajaramanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Mehar Afshan AmanullaNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Thongadi Ramesh DineshaYRG Center for AIDS Research and Education, Chennai, India.
Selvamuthu PoongulaliCART CRS, Infectious Diseases Medical Center, VHS, Chennai, India.
Shanmugam SaravananYRG Center for AIDS Research and Education, Chennai, India.
Kailapuri Gangatharan MurugavelYRG Center for AIDS Research and Education, Chennai, India.
Soumya SwaminathanNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Vijayakumar VeluDivision of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory Universitygrid.189967.8, Atlanta, Georgia, USA.ORCID 0000-0003-4238-1924
Barbara ShacklettDepartment of Medical Microbiology and Immunology, School of Medicine, University of California, Davisgrid.27860.3b, California, USA.
Ujjwal NeogiDivision of Clinical Microbiology, Karolinska Institutegrid.4714.6, Stockholm, Sweden.ORCID 0000-0002-0844-3338
Luke Elizabeth HannaNational Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India.
Indian Council of Medical Research · INKarolinska Institutet · SEYR Gaitonde Centre for AIDS Research and Education · INEmory University · USManipal Academy of Higher Education · INUniversity of California, Davis · USVoluntary Health Services Hospital · IN

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Viral Testing Core-Maintenance of the SPF Breeding Colonies at Yerkes National Primate Research CenterU42OD011023 · OD · EMORY UNIVERSITY · PI Matthew Ryan Gardner · 2018 to 2026
$17.5M
Combined cytokine therapy for sustained HIV remissionR01AI148377 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO, VELU, VIJAYAKUMAR · 2020 to 2024
$4.6M
CORRELATES OF MUCOSAL HIV-1 TRANSMISSION IN INDIAN WOMENR03AI062420 · NIAID · YRG CENTRE FOR AIDS RESEARCH & EDUCATION · PI SOLOMON, SUNITI · 2006 to 2008
$158k
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI148377NIAID NIH HHS R03 AI062420NIH HHS P51 OD011132NIH HHS U42 OD011023
6 · The paper itself

Abstract

The female genital tract (FGT) is an important site of human immunodeficiency virus (HIV) infection. Discerning the nature of HIV-specific local immune responses is crucial for identifying correlates of protection in HIV-exposed seronegative (HESN) individuals. The present study involved a comprehensive analysis of soluble immune mediators, secretory immunoglobulins (sIg), natural killer (NK) cells, CXCR5

Indexed as

MicrobiotaAdultBacteriaCD8-Positive T-LymphocytesCytokinesEsophageal MucosaFemaleHIV InfectionsHIV SeronegativityHumansImmunity, MucosalKiller Cells, NaturalT Follicular Helper CellsT-Lymphocytes, RegulatoryVignaYoung AdultCytokinesB cellsCBAcervicovaginal lavagecervicovaginal microbiotaCXCR5+ CD8+ cellscytobrushHESNmemory B cellsNK cellsTfh cellsTSCM cells

Identifiers

PMID34704803
PMCPMC8549735
OpenAlexW3162065709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.