Evidence map›Paper›PMID 34704535›Full record

ArticleChannels (Austin, Tex.)2021

Regulation of acid-sensing ion channels by protein binding partners.

Megan M Cullinan, Robert C Klipp, John R Bankston

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Progress on functions of intracellular domainZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan M CullinanDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Robert C KlippDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
John R BankstonDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-9478-2335
University of Colorado Anschutz Medical Campus · US

Funding

POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
Dynamics of Acid-sensing ion channelsR35GM137912 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI John Bankston · 2020 to 2026
$2.8M
Function and regulation of acid-sensing ion channels in corneal neuronsR00EY024267 · NEI · UNIVERSITY OF COLORADO DENVER · PI BANKSTON, JOHN · 2017 to 2019
$747k
Structural Mechanisms of Acid Sensing Ion ChannelsF31DE028739 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI CULLINAN, MEGAN · 2019 to 2021
$105k
NEI NIH HHS R00 EY024267NHLBI NIH HHS T32 HL007822NIDCR NIH HHS F31 DE028739NIGMS NIH HHS R35 GM137912
6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels that contribute to a diverse array of functions including pain sensation, cell death during ischemia, and more broadly to neurotransmission in the central nervous system. There is an increasing interest in understanding the physiological regulatory mechanisms of this family of channels. ASICs have relatively short N- and C-termini, yet a number of proteins have been shown to interact with these domains both

Indexed as

Acid Sensing Ion ChannelsNeuronsCell MembraneProtein BindingAcid Sensing Ion Channelsaccessory proteinsAcid-sensing ion channelsbinding partnersPSD-95RIPK1stomatin

Identifiers

PMID34704535
PMCPMC8555555
OpenAlexW3209438851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.