SynthesisInfluenza and other respiratory viruses2022
The burden of seasonal influenza in Italy: A systematic review of influenza-related complications, hospitalizations, and mortality.
Synthesis in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.Lancet (London, England) · 2024Pooled it
- Pooled it
- The burden of seasonal influenza in Italy: A systematic review of influenza-related complications, hospitalizations, and mortality.Influenza and other respiratory viruses · 2022Pooled it
- What shapes influenza attitudes and behaviors in Italy? Insights from a cross-sectional study.Human vaccines & immunotherapeutics · 2026Article
- Coverage and appropriateness of influenza vaccination in adults ≥ 60 y: Provider contribution and adherence to Italian national recommendations.Human vaccines & immunotherapeutics · 2026Article
- The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.ERJ open research · 2026Article
- The University of Salerno's Model for Seasonal Influenza Vaccinations in the Workplace.Vaccines · 2026Article
- Coefficient of variation-defined glycemic variability is associated with ICU mortality in critically ill influenza patients.BMC infectious diseases · 2026Article
- Global, regional, and national burden of influenza-associated lower respiratory infections, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021.BMC infectious diseases · 2026Article
- High-throughput pseudovirus neutralisation maps the antigenic landscape of influenza A/H1N1 viruses.EBioMedicine · 2025Article
- Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons.Viruses · 2025Observational
- Estimated impact of 2022-2023 influenza vaccines on annual hospital burden in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Reactogenicity of an Inactivated, Split-Virion Quadrivalent Influenza Vaccine in Infants and Children Aged ≥6 Months to <9 Years.Vaccines · 2025Article
- Article
- Article
- An integrated pathway for influenza vaccination across primary and secondary care using a clinical decision support system: model definition and predictive impact analysis.European journal of public health · 2024Article
- Cost-Effectiveness of Influenza Vaccination in Healthy Children: A 10-Year Population-Based Study.Vaccines · 2024Article
- Development and validation of a nomogram to predict severe influenza.Immunity, inflammation and disease · 2024Article
- Influenza disease burden and the need for highly immunogenic vaccines in older adults: a narrative review.Ewha medical journal · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable country-specific data on influenza burden play a crucial role in informing prevention and control measures. Our purpose was to provide a comprehensive summary of the available evidence on the burden of seasonal influenza in Italy. We performed a systematic literature review of articles published until July 31, 2020. PubMed, Embase, and Web of Science were searched using terms related to burden, influenza, and Italian population. We included studies investigating seasonal influenza-related complications, hospitalizations, and/or mortality. Sixteen studies were included: eight (50%) analyzed influenza-related complications, eight (50%) hospitalizations, and seven (43.8%) influenza-related deaths. Only three studies (19.7%) concerned pediatric age. The synthesis of results showed that patients with chronic conditions have an increased risk for complications up to almost three times as compared with healthy people. Hospitalizations due to influenza can occur in as much as 5% of infected people depending on the study setting. Excess deaths rates were over sixfold higher in the elderly as compared with the rest of population. Although there are still gaps in existing data, there is evidence of the significant burden that influenza places each year especially on high-risk groups. These data should be used to inform public health decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.