Evidence map›Paper›PMID 34704330›Full record

ArticleHIV medicine2022

Statin usage and cardiovascular risk among people living with HIV in the U.S. Military HIV Natural History Study.

Derek Larson, Seung Hyun Won, Anuradha Ganesan, Ryan C Maves, Karl Kronmann, Jason F Okulicz, Xiuping Chu, Christina Schofield, Thomas O'Bryan, Brian K Agan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Incidence of Statin Initiation Among People With and Without HIV in the United States: A Prospective Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · on this map
    Observational
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Derek LarsonFort Belvoir Community Hospital, Fort Belvoir, Virginia, USA.ORCID 0000-0002-6147-7182
Seung Hyun WonInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Anuradha GanesanInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Ryan C MavesInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Karl KronmannNaval Medical Center Portsmouth, Portsmouth, Virginia, USA.
Jason F OkuliczInfectious Disease Service, Brooke Army Medical Center, San Antonio, Texas, USA.
Xiuping ChuInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Christina SchofieldMadigan Army Medical Center, Tacoma, Washington, USA.
Thomas O'BryanInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Brian K AganInfectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.ORCID 0000-0002-5114-1669
Robert DeissUniversity of California, San Diego, La Jolla, California, USA.
Henry M. Jackson Foundation · USAlexander T. Augusta Military Medical Center · USBrooke Army Medical Center · USMadigan Army Medical Center · USNaval Medical Center Portsmouth · USNaval Medical Center San Diego · USUniversity of California San Diego · US

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
–
NIAID NIH HHS Y01 AI005072
6 · The paper itself

Abstract

objectivesUsing the American College of Cardiology/American Heart Association 2013 atherosclerotic cardiovascular disease (ASCVD) management guidelines, we conducted a retrospective cross-sectional analysis of people living with HIV in the US Military HIV Natural History Study to determine whether individuals were receiving statins when indicated.

methodsPrescription data was taken from Military Health System data. Statin eligibility was defined by ASCVD guidelines. We used the 10-year ASCVD pooled cohorts' equation to evaluate risk for each participant.

resultsAcross all categories, 31.9% (n = 390) of individuals met criteria for statin use, and when adding these subjects to the number of those already receiving statins (n = 96), 62.1% of all eligible subjects (n = 302/486) were actually receiving statin therapy. In multivariable analysis, individuals of African American race [odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.31-0.73] or Hispanic ethnicity (OR = 0.42, 95% CI: 0.19-0.94) were less likely to receive statin prescriptions than white individuals. Individuals with a higher CD4 count (OR = 1.12, 95% CI: 1.05-1.20 per 100 cells/μL]) were significantly more likely to receive a statin prescription.

conclusionsThese data highlight discrepancies between ASCVD guidelines and primary care management of people living with HIV (PLWH) in the military health system, along with important racial differences. Targeted interventions are critical to identify and treat appropriate candidates for statin therapy among PLWH in the military and other settings.

Indexed as

Cardiovascular DiseasesHIV InfectionsHydroxymethylglutaryl-CoA Reductase InhibitorsCross-Sectional StudiesHeart Disease Risk FactorsHumansRetrospective StudiesRisk FactorsUnited StatesHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseaseHIVmilitarypreventative medicineprimary carestatin

Identifiers

PMID34704330
PMCPMC8847313
OpenAlexW3211119773

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.