Evidence map›Paper›PMID 34704196›Full record

ArticleBiological trace element research2022

Hepatotoxic and Neurotoxic Potential of Iron Oxide Nanoparticles in Wistar Rats: a Biochemical and Ultrastructural Study.

Mostafa Mabrouk, Ghadha Ibrahim Fouad, Sara A M El-Sayed, Maha Z Rizk, Hanan H Beherei

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Toxicologic Concerns with Current Medical Nanoparticles.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mostafa MabroukRefractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St, PO Box 12622, Dokki, Cairo, Egypt.
Ghadha Ibrahim FouadDepartment of Therapeutic Chemistry, National Research Centre, 33 El-Bohouth St, 12622, Dokki, Cairo, Egypt. ghadhaibrahim@yahoo.com.ORCID http://orcid.org/0000-0003-3665-3153
Sara A M El-SayedRefractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St, PO Box 12622, Dokki, Cairo, Egypt.
Maha Z RizkDepartment of Therapeutic Chemistry, National Research Centre, 33 El-Bohouth St, 12622, Dokki, Cairo, Egypt.
Hanan H BehereiRefractories, Ceramics and Building Materials Department, National Research Centre, 33 El Bohouth St, PO Box 12622, Dokki, Cairo, Egypt.
National Research Centre · EG

Funding

national research centre 120-60-106
6 · The paper itself

Abstract

Iron oxide nanoparticles (IONPs) are increasingly being employed for in vivo biomedical nanotheranostic applications. The development of novel IONPs should be accompanied by careful scrutiny of their biocompatibility. Herein, we studied the effect of administration of three formulations of IONPs, based on their starting materials along with synthesizing methods, IONPs-chloride, IONPs-lactate, and IONPs-nitrate, on biochemical and ultrastructural aspects. Different techniques were utilized to assess the effect of different starting materials on the physical, morphological, chemical, surface area, magnetic, and particle size distribution accompanied with their surface charge properties. Their nanoscale sizes were below 40 nm and demonstrated surface up to 69m

Indexed as

Magnetite NanoparticlesNanoparticlesAnimalsBrainChloridesFerric CompoundsIronMagnetic Iron Oxide NanoparticlesRatsRats, WistarChloridesFerric CompoundsIronMagnetite NanoparticlesAnimal clinical observationsIn vivoIron oxide nanoparticlesMagnetiteNanotoxicityRats

Identifiers

PMID34704196
OpenAlexW3210192575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.