Evidence map›Paper›PMID 34704164›Full record

ArticleAnnals of biomedical engineering2021

Local Renin-Angiotensin System Signaling Mediates Cellular Function of Aortic Valves.

Asya Ozkizilcik, Fah Sysavanh, Smit Patel, Ishita Tandon, Kartik Balachandran

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Asya OzkizilcikDepartment of Biomedical Engineering, University of Arkansas, 122 John A.White Jr. Engineering Hall, Fayetteville, AR, 72701, USA.
Fah SysavanhDepartment of Biomedical Engineering, University of Arkansas, 122 John A.White Jr. Engineering Hall, Fayetteville, AR, 72701, USA.
Smit PatelDepartment of Biomedical Engineering, University of Arkansas, 122 John A.White Jr. Engineering Hall, Fayetteville, AR, 72701, USA.
Ishita TandonDepartment of Biomedical Engineering, University of Arkansas, 122 John A.White Jr. Engineering Hall, Fayetteville, AR, 72701, USA.
Kartik BalachandranDepartment of Biomedical Engineering, University of Arkansas, 122 John A.White Jr. Engineering Hall, Fayetteville, AR, 72701, USA. kbalacha@uark.edu.ORCID http://orcid.org/0000-0002-8550-822X
University of Arkansas at Fayetteville · US

Funding

american heart association 18AIREA33900098american heart association 19PRE34370061
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) is activated in aortic valve disease, yet little is understood about how it affects the acute functional response of valve interstitial cells (VICs). Herein, we developed a gelatin-based valve thin film (vTF) platform to investigate whether the contractile response of VICs can be regulated via RAS mediators and inhibitors. First, the impact of culture medium (quiescent, activated, and osteogenic medium) on VIC phenotype and function was assessed. Contractility of VICs was measured upon treatment with angiotensin I (Ang I), angiotensin II (Ang II), angiotensin-converting enzyme (ACE) inhibitor, and Angiotensin II type 1 receptor (AT

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin IAngiotensin IIAnimalsAortic ValveCells, CulturedFluorescent Antibody TechniqueLosartanMyofibroblastsPeptidyl-Dipeptidase AReceptor, Angiotensin, Type 1Renin-Angiotensin SystemSwineTetrahydroisoquinolinesAngiotensin-Converting Enzyme InhibitorsAngiotensin IAngiotensin IILosartanPeptidyl-Dipeptidase AquinaprilatReceptor, Angiotensin, Type 1TetrahydroisoquinolinesAngiotensinGelatinMicrofabricationOrgans on chipsTissue engineeringValve interstitial cells

Identifiers

PMID34704164
OpenAlexW3209121256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.