Evidence map›Paper›PMID 34704141›Full record

ArticleJournal of clinical immunology2022

Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan.

Sho Hosaka, Takahiro Kido, Kazuo Imagawa, Hiroko Fukushima, Tomohiro Morio, Shigeaki Nonoyama, Hidetoshi Takada

Erratum issuedAbstract read
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In one paragraph

Article in Journal of clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. Review
  8. Infection prevention in patients with inborn errors of immunity: Insights from Japan's nationwide study.Pediatrics international : official journal of the Japan Pediatric Society
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sho HosakaDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan. shohosaka@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0002-2792-1235
Takahiro KidoDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan.
Kazuo ImagawaDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan.
Hiroko FukushimaDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan.
Tomohiro MorioDepartment of Pediatrics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Shigeaki NonoyamaDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Hidetoshi TakadaDepartment of Pediatrics, University of Tsukuba Hospital, Ibaraki, Japan.
University of Tsukuba · JPUniversity of Tsukuba Hospital · JPNational Defense Medical College · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a nationwide survey of inborn errors of immunity (IEI) in Japan for the second time in 10 years, focusing on protective measures for IEI patients against infectious diseases. Questionnaires were sent to various medical departments nationwide, and a total of 1307 patients were reported. The prevalence of IEI was 2.2 patients per 100,000 population, which was comparable with the previous nationwide study. The most common disease category was autoinflammatory disorders (25%), followed by antibody deficiencies (24%) and congenital defects of phagocyte number or function (16%). We found that a significant number of patients received contraindicated vaccines, principally because the patients were not diagnosed with IEI by the time of the vaccination. Regarding diseases for which BCG vaccination is contraindicated, 43% of patients had actually received BCG, of which 14% developed BCG-related infections. BCG-related infections were mainly observed among patients with CGD and MSMD. In order to prevent IEI patients from receiving inadequate vaccines, continuous education to parents and physicians is needed, along with the expansion of newborn screening, but efforts to screen IEI at the site of vaccination also remain important.

Indexed as

Primary Immunodeficiency DiseasesHumansInfant, NewbornJapanPrevalenceSurveys and QuestionnairesVaccinationBCGEpidemiologyInborn errors of immunityJapanVaccine

Identifiers

PMID34704141
OpenAlexW3183519859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.