Observational studyPediatric nephrology (Berlin, Germany)2022
Abnormal magnesium levels and their impact on death and acute kidney injury in critically ill children.
Observational study in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Serum Magnesium Levels as a Prognostic Marker in Emergency Department Admissions: A Landmark Retrospective Cohort Study.Journal of the American College of Emergency Physicians open · 2026Article
- Machine learning early risk assessment model for acute kidney injury in critically ill children: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Association of magnesium sulphate use with mortality in patients with acute respiratory distress syndrome: a retrospective propensity score-matched cohort study.Scientific reports · 2025Article
- Magnesium disturbances in critically ill children.Scientific reports · 2025Observational
- The development and validation of a prediction model for post-AKI outcomes of pediatric inpatients.Clinical kidney journal · 2025Article
- Article
- The role of serum magnesium in the prediction of acute kidney injury after total aortic arch replacement: A prospective observational study.Journal of medical biochemistry · 2024Article
- Association of early postoperative serum magnesium with acute kidney injury after cardiac surgery.Renal failure · 2023Article
- Nutritional management of children with acute kidney injury-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Exploiting Machine Learning Technologies to Study the Compound Effects of Serum Creatinine and Electrolytes on the Risk of Acute Kidney Injury in Intensive Care Units.Diagnostics (Basel, Switzerland) · 2023Article
- Role of Magnesium in the Intensive Care Unit and Immunomodulation: A Literature Review.Vaccines · 2023Review
- Hypomagnesemia Is Associated with the Acute Kidney Injury in Traumatic Brain Injury Patients: A Pilot Study.Brain sciences · 2023Article
- Prevalence and predictors of magnesium imbalance among critically ill diarrheal children and their outcome in a developing country.PloS one · 2023Article
- Initial Serum Magnesium Level Is Associated with Mortality Risk in Traumatic Brain Injury Patients.Nutrients · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of magnesium imbalance in critically ill children is very high. However, its significance in the development of acute kidney injury (AKI) and mortality remains unknown.
methodsIn this retrospective observational study from 2010 to 2018, the pediatric-specific intensive care database was analyzed. We included critically ill children aged > 3 months and those without chronic kidney disease. Patients were diagnosed with AKI, according to the Kidney Disease Improving Global Outcomes (KDIGO) study. We calculated the initial corrected magnesium levels (cMg) within 24 h and used a spline regression model to evaluate the cut-off values for cMg. We analyzed 28-day mortality and its association with AKI. The interaction between AKI and magnesium imbalance was evaluated.
resultsThe study included 3,669 children, of whom 105 died within 28 days, while 1,823 were diagnosed with AKI. The cut-off values for cMg were 0.72 and 0.94 mmol/L. Both hypermagnesemia and hypomagnesemia were associated with 28-day mortality (odds ratio [OR] = 2.99, 95% confidence interval [CI] = 1.89-4.71, p < 0.001; OR = 2.80, 95% CI = 1.60-4.89, p < 0.001). Hypermagnesemia was associated with AKI (OR = 1.52, 95% CI = 1.27-1.82, p < 0.001), while neither hypermagnesemia nor hypomagnesemia interacted with the AKI stage on the 28-day mortality.
conclusionsAbnormal magnesium levels were associated with 28-day mortality in critically ill children. AKI and hypermagnesemia had a strong association. "A higher resolution version of the Graphical abstract is available as Supplementary information".
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