ArticleNeuroradiology2022
Time-resolved assessment of cortical venous drainage on multiphase CT angiography in patients with acute ischemic stroke.
Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 16 citations in OpenAlex.
- The value of multiphase CT angiography in predicting hemorrhagic transformation after endovascular treatment: the arterial collaterals and venous drainage.Quantitative imaging in medicine and surgery · 2026Article
- Unfavorable venous outflow correlates with poor prognosis in acute ischemic stroke due to large vessel occlusion (AIS-LVO) patients assessed dynamically and quantitatively based on four-dimensional computed tomography angiography/perfusion (4D-CTA/CTP).Quantitative imaging in medicine and surgery · 2025Article
- Role of Venous Delay on Stroke Outcome: Prospective Evaluation Before and After Mechanical Thrombectomy.Journal of stroke · 2024Article
- Difference between arterial and venous peak optical density after thrombectomy is associated with functional outcomes.Frontiers in neurology · 2024Article
- Pivotal role of multiphase computed tomography angiography for collateral assessment in patients with acute ischemic stroke.La Radiologia medica · 2023Review
- Stroke recurrence is associated with unfavorable intracranial venous outflow in patients with symptomatic intracranial atherosclerotic large vessel severe stenosis or occlusion.Frontiers in neurology · 2023Article
- Delayed CTP-Derived Deep Venous Outflow: A Novel Predictor of Striatocapsular Infarction after M1 Thrombectomy.AJNR. American journal of neuroradiology · 2022Article
- Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy.Stroke (Hoboken, N.J.) · 2022Article
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Authors and funding
12 authors at 7 institutions in 4 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeCortical vein opacification is not routinely assessed in patients presenting with acute ischemic stroke (AIS), and the value of temporal assessment of venous outflow is not known. We evaluated the utility of assessing cortical venous drainage over time using multiphase CT angiography (mCTA).
methodsCortical venous drainage was assessed in patients from the Precise and Rapid Assessment of Collaterals Using Multi-Phase CTA in the Triage of Patients With Acute Ischemic Stroke for IA Therapy prospective multicenter cohort study of patients with symptoms of AIS with ICA and/or middle cerebral artery occlusion on baseline mCTA. Opacification of vein of Labbe, sphenoparietal sinus, superficial middle cerebral vein, and vein of Trolard of the affected hemisphere was graded as no (0), partial (1), or full (2) opacification in each mCTA phase. The venous opacification scores for each phase were added to generate a total venous score (TVS) (range 0-24). Primary outcome was 90-day modified Rankin score. Repeated measures analysis was used to assess the effect of phase timing on venous score on outcome.
resultsOf 432 patients, 284 (65.7%) had proximal arterial occlusions. Median venous opacification score per phase (range 0-8) was 3 (IQR 1-6) in the first phase and increased in the second and third phases [median (IQR): 6 (5-8) and 8 (6-8), respectively] of the mCTA. In a multivariable analysis adjusting for age, baseline National Institutes of Health Stroke Scale, and Alberta stroke program early CT score, a significant association between TVS and 90-day mRS was noted ([adjusted cOR for TVS 6-11: 0.16 (95% CI 0.05-0.51); TVS 12-17: 0.18 (95% CI 0.06-0.57); TVS 18-24: 0.20 (0.06-0.63)]. Repeated measures analysis of venous scores from all three phases showed a significant effect of time/phase on TVS (p < 0.001).
conclusionThis study concludes that venous opacification over time on multiphase CTA is associated with 90-day clinical outcome. There was however no added benefit of venous scoring vis-a-vis arterial collateral assessment in predicting outcome.
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