Evidence map›Paper›PMID 34704080›Full record

ArticleBrain, behavior, & immunity - health2021

Immunological effects of cerebral palsy and rehabilitation exercises in children.

Oleksandra Sharova, Oleksandr Smiyan, Thomas Borén

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  4. Article
  5. Inflammation, Dopaminergic Brain and Bilirubin.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Oleksandra SharovaDepartment of Pediatrics, Sumy State University, 40031, Sumy, Ukraine.
Oleksandr SmiyanDepartment of Pediatrics, Sumy State University, 40031, Sumy, Ukraine.
Thomas BorénDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-90187, Umeå, Sweden.
Sumy State University · UAUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral palsy (CP) is a group of motor disorders caused by non-progressive lesions of the premature brain with lifelong pathophysiological consequences that include dysregulation of innate immunity. Persistent inflammation with increased levels of circulating pro-inflammatory tumor necrosis factor alpha (TNF-a) is negatively associated with rehabilitation outcome in children with CP. Because of the crosstalk between innate and adaptive immunity, we investigated the effect of CP and rehabilitation exercises on the adaptive immune system in children with CP by measuring the levels of CD3

Indexed as

CD22+ B-cellsCD3, cluster of differentiation 3Children with cerebral palsyCP, cerebral palsyCRP, C-reactive proteinGMFCS, Gross Motor Function Classification System for Cerebral PalsyGMFM-88, Gross Motor Function Measure-88IgAIgG, immunoglobulin GIL-6, interleukin 6RehabilitationT-cellsTNF-aTNF-a, tumor necrosis factor alpha

Identifiers

PMID34704080
PMCPMC8522480
OpenAlexW3207138475

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.