Evidence map›Paper›PMID 34704059›Full record

ArticleRSC chemical biology2021

Macrocyclic peptides as allosteric inhibitors of nicotinamide

Matthijs J van Haren, Yurui Zhang, Vito Thijssen, Ned Buijs, Yongzhi Gao, Lukasz Mateuszuk, Filip A Fedak, Agnieszka Kij, Roberto Campagna, Davide Sartini and 4 more

Open access · goldAbstract read
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Efficacious Anti-Cancer Drugs Targeting NicotinamidePharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Matthijs J van HarenBiological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.ORCID https://orcid.org/0000-0003-0251-071X
Yurui ZhangBiological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.
Vito ThijssenChemical Biology & Drug Discovery Group, Utrecht Institute for Pharmaceutical Sciences Universiteitsweg 99 3584 CG Utrecht The Netherlands s.a.k.jongkees@vu.nl.
Ned BuijsBiological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.
Yongzhi GaoBiological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.
Lukasz MateuszukJagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET) Bobrzynskiego 14 30-348 Krakow Poland.
Filip A FedakJagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET) Bobrzynskiego 14 30-348 Krakow Poland.
Agnieszka KijJagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET) Bobrzynskiego 14 30-348 Krakow Poland.
Roberto CampagnaDepartment of Clinical Sciences, Universitá Politecnica delle Marche Via Ranieri 65 60131 Ancona Italy.
Davide SartiniDepartment of Clinical Sciences, Universitá Politecnica delle Marche Via Ranieri 65 60131 Ancona Italy.
Monica EmanuelliDepartment of Clinical Sciences, Universitá Politecnica delle Marche Via Ranieri 65 60131 Ancona Italy.
Stefan ChlopickiJagiellonian University, Jagiellonian Centre for Experimental Therapeutics (JCET) Bobrzynskiego 14 30-348 Krakow Poland.
Seino A K JongkeesChemical Biology & Drug Discovery Group, Utrecht Institute for Pharmaceutical Sciences Universiteitsweg 99 3584 CG Utrecht The Netherlands s.a.k.jongkees@vu.nl.ORCID https://orcid.org/0000-0002-4796-0557
Nathaniel I MartinBiological Chemistry Group, Institute of Biology Leiden, Leiden University Sylviusweg 72 2333 BE Leiden The Netherlands n.i.martin@biology.leidenuniv.nl.ORCID https://orcid.org/0000-0001-8246-3006
Leiden University · NLJagiellonian University · PLMarche Polytechnic University · ITVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide

Identifiers

PMID34704059
PMCPMC8496086
OpenAlexW3193834055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.