Evidence map›Paper›PMID 34704054›Full record

ArticleRSC chemical biology2021

Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling.

Marcus E Graziotto, Liam D Adair, Amandeep Kaur, Pauline Vérité, Sarah R Ball, Margaret Sunde, Denis Jacquemin, Elizabeth J New

Abstract read
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcus E GraziottoThe University of Sydney, School of Chemistry NSW 2006 Australia elizabeth.new@sydney.edu.au.ORCID https://orcid.org/0000-0002-8157-2021
Liam D AdairThe University of Sydney, School of Chemistry NSW 2006 Australia elizabeth.new@sydney.edu.au.ORCID https://orcid.org/0000-0002-9527-4869
Amandeep KaurThe University of Sydney, School of Medical Sciences, Faculty of Medicine and Health NSW 2006 Australia.ORCID https://orcid.org/0000-0002-0898-875X
Pauline VéritéCEISAM Lab, CNRS, Université de Nantes Nantes France.
Sarah R BallThe University of Sydney, School of Medical Sciences, Faculty of Medicine and Health NSW 2006 Australia.
Margaret SundeThe University of Sydney, School of Medical Sciences, Faculty of Medicine and Health NSW 2006 Australia.ORCID https://orcid.org/0000-0002-0150-3203
Denis JacqueminCEISAM Lab, CNRS, Université de Nantes Nantes France.ORCID https://orcid.org/0000-0002-4217-0708
Elizabeth J NewThe University of Sydney, School of Chemistry NSW 2006 Australia elizabeth.new@sydney.edu.au.ORCID https://orcid.org/0000-0002-2310-254X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent probes for biological imaging have revealed much about the functions of biomolecules in health and disease. Fluorogenic probes, which are fluorescent only upon a bioorthogonal reaction with a specific partner, are particularly advantageous as they ensure that fluorescent signals observed in biological imaging arise solely from the intended target. In this work, we report the first series of naphthalimide tetrazines for bioorthogonal fluorogenic labelling. We establish that all of these compounds can be used for imaging through photophysical, analytical and biological studies. The best candidate was

Identifiers

PMID34704054
PMCPMC8496007

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.