Evidence map›Paper›PMID 34704053›Full record

ArticleRSC chemical biology2021

Computational design and experimental characterization of a photo-controlled mRNA-cap guanine-N7 methyltransferase.

Dennis Reichert, Helena Schepers, Julian Simke, Horst Lechner, Wolfgang Dörner, Birte Höcker, Bart Jan Ravoo, Andrea Rentmeister

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dennis ReichertInstitute of Biochemistry, University of Münster, Correnstraße 36 Münster 48149 Germany a.rentmeister@uni-muenster.de.
Helena SchepersInstitute of Biochemistry, University of Münster, Correnstraße 36 Münster 48149 Germany a.rentmeister@uni-muenster.de.
Julian SimkeOrganic Chemistry Institute, University of Münster, Corrensstraße 36 Münster 48149 Germany.
Horst LechnerDepartment for Biochemistry, University of Bayreuth, Universitätsstraße 30 Bayreuth 95447 Germany.
Wolfgang DörnerInstitute of Biochemistry, University of Münster, Correnstraße 36 Münster 48149 Germany a.rentmeister@uni-muenster.de.
Birte HöckerDepartment for Biochemistry, University of Bayreuth, Universitätsstraße 30 Bayreuth 95447 Germany.ORCID https://orcid.org/0000-0002-8250-9462
Bart Jan RavooCells in Motion Interfaculty Center, University of Münster Münster 48149 Germany.
Andrea RentmeisterInstitute of Biochemistry, University of Münster, Correnstraße 36 Münster 48149 Germany a.rentmeister@uni-muenster.de.ORCID https://orcid.org/0000-0002-3107-4147
University of Münster · DEGraz University of Technology · ATUniversity of Bayreuth · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spatial and temporal control of gene expression at the post-transcriptional level is essential in eukaryotic cells and developing multicellular organisms. In recent years optochemical and optogenetic tools have enabled the manipulation and investigation of many steps in the involved processes. However, examples for light-mediated control of eukaryotic mRNA processing and the responsible enzymes are still rare. In particular, methylation of the 5' cap of mRNA is required for ribosome assembly, and the responsible guanine-N7 methyltransferase (MTase) from

Identifiers

PMID34704053
PMCPMC8495969
OpenAlexW3174430019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.