Evidence map›Paper›PMID 34704051›Full record

ArticleRSC chemical biology2021

Towards optimizing peptide-based inhibitors of protein-protein interactions: predictive saturation variation scanning (PreSaVS).

Kristina Hetherington, Som Dutt, Amaurys A Ibarra, Emma E Cawood, Fruzsina Hobor, Derek N Woolfson, Thomas A Edwards, Adam Nelson, Richard B Sessions, Andrew J Wilson

Abstract read
In one paragraph

Article in RSC chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Discovery of SARS-CoV-2 MChemical science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristina HetheringtonAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
Som DuttAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
Amaurys A IbarraSchool of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.
Emma E CawoodAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.ORCID https://orcid.org/0000-0002-2707-8022
Fruzsina HoborAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.
Derek N WoolfsonSchool of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.ORCID https://orcid.org/0000-0002-0394-3202
Thomas A EdwardsAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.ORCID https://orcid.org/0000-0002-1467-3674
Adam NelsonAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.ORCID https://orcid.org/0000-0003-3886-363X
Richard B SessionsSchool of Biochemistry, University of Bristol, Medical Sciences Building, University Walk Bristol BS8 1TD UK r.sessions@bristol.ac.uk.ORCID https://orcid.org/0000-0003-0320-0895
Andrew J WilsonAstbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK a.j.wilson@leeds.ac.uk.ORCID https://orcid.org/0000-0001-9852-6366

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1
6 · The paper itself

Abstract

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

Identifiers

PMID34704051
PMCPMC8495968

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.