Evidence map›Paper›PMID 34704022›Full record

ArticleBrain communications2021

Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson's disease.

Nicolaas I Bohnen, Prabesh Kanel, Robert A Koeppe, Carlos A Sanchez-Catasus, Kirk A Frey, Peter Scott, Gregory M Constantine, Roger L Albin, Martijn L T M Müller

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 49 citations in OpenAlex.

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  8. Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.ORCID https://orcid.org/0000-0003-0352-6414
Prabesh KanelDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.ORCID https://orcid.org/0000-0003-1418-2960
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.
Carlos A Sanchez-CatasusDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.
Kirk A FreyDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.
Peter ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.
Gregory M ConstantineDepartment of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, MI 48105, USA.
Martijn L T M MüllerDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105, USA.
University of Michigan · USUniversity of Pittsburgh · US

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOEPPE, ROBERT A · 1985 to 2012
$13.0M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856RRD VA I01 RX001631
6 · The paper itself

Abstract

Clinical effects of anti-cholinergic drugs implicate cholinergic systems alterations in the pathophysiology of some cardinal motor impairments in Parkinson's disease. The topography of affected cholinergic systems deficits and motor domain specificity are poorly understood. Parkinson's disease patients (

Indexed as

acetylcholinecerebellummedial geniculate nucleusmotor impairmentsParkinson's disease

Identifiers

PMID34704022
PMCPMC8196256
OpenAlexW3165513721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.