ArticleBrain communications2021
Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Diffusion MRI sampling schemes bias diffusion metrics and tractography.Frontiers in neuroimaging · 2026Article
- From Overgrowth to Complex Malformations: A NovelChildren (Basel, Switzerland) · 2025Article
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Comprehensive mapping of the thalamic commissures in the rodent brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Review
- Direct interhemispheric cortical communication via thalamic commissures: a new white matter pathway in the primate brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The relevance of heterotopic callosal fibers to interhemispheric connectivity of the mammalian brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Brain plasticity following corpus callosum agenesis or loss: a review of the Probst bundles.Frontiers in neuroanatomy · 2023Review
- Heterotopic connectivity of callosal dysgenesis in mice and humans.Frontiers in neuroscience · 2023Article
- Review
- Inflammatory Response and Secondary White Matter Damage to the Corpus Callosum after Focal Striatal Stroke in Rats.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Developmental malformations (dysgenesis) of the corpus callosum lead to neurological conditions with a broad range of clinical presentations. Investigating the altered brain connectivity patterns is crucial to understanding both adaptive and maladaptive neuroplasticity in corpus callosum dysgenesis patients. Here, we acquired structural diffusion-weighted and resting-state functional MRI data from a cohort of 11 corpus callosum dysgenesis patients (five with agenesis and six with hypoplasia) and compared their structural and functional connectivity patterns to healthy subjects selected from the Human Connectome Project. We found that these patients have fewer structural inter- and intra-hemispheric brain connections relative to healthy controls. Interestingly, the patients with callosal agenesis have a scant number of inter-hemispheric connections but manage to maintain the full integrity of functional connectivity between the same cortical regions as the healthy subjects. On the other hand, the hypoplasic group presented abnormal structural and functional connectivity patterns relative to healthy controls while maintaining the same total amount of functional connections. These results demonstrate that acallosal patients can compensate for having fewer structural brain connections and present functional adaptation. However, hypoplasics present atypical structural connections to different brain regions, leading to entirely new and abnormal functional brain connectivity patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.