Evidence map›Paper›PMID 34704019›Full record

ArticleBrain communications2021

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.

Anna Mallach, Johan Gobom, Henrik Zetterberg, John Hardy, Thomas M Piers, Selina Wray, Jennifer M Pocock

Open access · goldAbstract readComment
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Increased circulating TREM2Brain, behavior, & immunity - health · 2026
    Article
  3. Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Anna MallachDepartment of Neuroinflammation, Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK.
Johan GobomDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, S-431 80, Mölndal, Sweden.ORCID https://orcid.org/0000-0001-6193-6193
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, S-431 80, Mölndal, Sweden.
John HardyDepartment of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London WC1N 1PJ, UK.
Thomas M PiersDepartment of Neuroinflammation, Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK.
Selina WrayDepartment of Neurodegenerative Disease, University College London Queen Square Institute of Neurology, London WC1N 1PJ, UK.
Jennifer M PocockDepartment of Neuroinflammation, Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK.ORCID https://orcid.org/0000-0001-5812-9331
Queen Mary University of London · GBSahlgrenska University Hospital · SEHong Kong University of Science and Technology · HKNational Hospital for Neurology and Neurosurgery · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M009513/1Medical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L501542/1Parkinson's UK G-0907Parkinson's UK G-1307
6 · The paper itself

Abstract

Variants in the triggering receptor expressed on myeloid cells 2 gene are linked with an increased risk of dementia, in particular the R47H

Indexed as

Alzheimer’s diseaseexosomesmicrogliaTREM2

Identifiers

PMID34704019
PMCPMC8244649
OpenAlexW3126636354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.