Evidence map›Paper›PMID 34703624›Full record

ArticleVirus evolution2021

In action-an early warning system for the detection of unexpected or novel pathogens.

Pauline Dianne Santos, Ute Ziegler, Kevin P Szillat, Claudia A Szentiks, Birte Strobel, Jasmin Skuballa, Sabine Merbach, Pierre Grothmann, Birke Andrea Tews, Martin Beer and 1 more

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Climate-driven invasion ofOne health (Amsterdam, Netherlands) · 2026
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  9. Multiple Novel Mosquito-Borne Zoonotic Viruses Revealed in Pangolin Virome.Frontiers in cellular and infection microbiology · 2022
    Article
  10. Metagenomic Analysis ofFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Pauline Dianne SantosFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Diagnostic Virology, Südufer 10, Greifswald, Insel Riems 17493, Germany.ORCID https://orcid.org/0000-0003-4324-5967
Ute ZieglerFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, Greifswald, Insel Riems 17493, Germany.
Kevin P SzillatFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Diagnostic Virology, Südufer 10, Greifswald, Insel Riems 17493, Germany.ORCID https://orcid.org/0000-0003-1135-0244
Claudia A Szentiks4Department of Wildlife Diseases, Leibniz-Institute for Zoo- and Wildlife Research (IZW), Alfred-Kowalke-Straße 17, Berlin 10315, Germany.
Birte StrobelChemical and Veterinary Investigations Office Karlsruhe (CVUA Karlsruhe), Weissenburgerstrasse 3, Karlsruhe 76187, Germany.
Jasmin SkuballaChemical and Veterinary Investigations Office Karlsruhe (CVUA Karlsruhe), Weissenburgerstrasse 3, Karlsruhe 76187, Germany.
Sabine MerbachState Institute for Chemical and Veterinary Analysis (CVUA) Westfalen, Zur Taubeneiche 10-12, Arnsberg 59821, Germany.
Pierre GrothmannPractice for Zoo, Game and Wild Animals, Lintiger Str. 74, Geestland 27624, Germany.
Birke Andrea TewsFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Infectology, Südufer 10, Greifswald, Insel Riems 17493, Germany.
Martin BeerFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Diagnostic Virology, Südufer 10, Greifswald, Insel Riems 17493, Germany.
Dirk HöperFriedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Diagnostic Virology, Südufer 10, Greifswald, Insel Riems 17493, Germany.ORCID https://orcid.org/0000-0001-8408-2274
Friedrich-Loeffler-Institut · DEChemisches und Veterinäruntersuchungsamt Karlsruhe · DEChemisches und Veterinäruntersuchungsamt Ostwestfalen-Lippe · DELeibniz Institute for Zoo and Wildlife Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proactive approaches in preventing future epidemics include pathogen discovery prior to their emergence in human and/or animal populations. Playing an important role in pathogen discovery, high-throughput sequencing (HTS) enables the characterization of microbial and viral genetic diversity within a given sample. In particular, metagenomic HTS allows the unbiased taxonomic profiling of sequences; hence, it can identify novel and highly divergent pathogens such as viruses. Newly discovered viral sequences must be further investigated using genomic characterization, molecular and serological screening, and/or

Indexed as

birdearly warning systemGermanyHedwig virushigh-throughput sequencing (HTS)metagenomicsmosquitosoutbreakPeribunyaviridaeReoviridaeUmatilla virus

Identifiers

PMID34703624
PMCPMC8542707
OpenAlexW3202765466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.