Evidence map›Paper›PMID 34703558›Full record

ArticleChemical science2021

Sulfated poly-amido-saccharides (sulPASs) are anticoagulants

Maria Varghese, Rae S Rokosh, Carolyn A Haller, Stacy L Chin, Jiaxuan Chen, Erbin Dai, Ruiqing Xiao, Elliot L Chaikof, Mark W Grinstaff

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Beyond nylon 6: polyamidesChemical Society reviews · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria VargheseDepartments of Chemistry, Biomedical Engineering, and Medicine, Boston University Boston MA 02215 USA mgrin@bu.edu mariavar@bu.edu stacy.chin@hydroglydecoatings.com xiaorq@mit.edu.ORCID https://orcid.org/0000-0001-9739-8454
Rae S RokoshDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University Boston MA USA echaikof@bidmc.harvard.edu rsrokosh@bidmc.harvard.edu challer@bidmc.harvard.edu jchen13@bidmc.harvard.edu edai@bidmc.harvard.edu mailto:echaikof@bidmc.harvard.edu.ORCID https://orcid.org/0000-0003-2832-5184
Carolyn A HallerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University Boston MA USA echaikof@bidmc.harvard.edu rsrokosh@bidmc.harvard.edu challer@bidmc.harvard.edu jchen13@bidmc.harvard.edu edai@bidmc.harvard.edu mailto:echaikof@bidmc.harvard.edu.ORCID https://orcid.org/0000-0003-1963-3695
Stacy L ChinDepartments of Chemistry, Biomedical Engineering, and Medicine, Boston University Boston MA 02215 USA mgrin@bu.edu mariavar@bu.edu stacy.chin@hydroglydecoatings.com xiaorq@mit.edu.
Jiaxuan ChenDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University Boston MA USA echaikof@bidmc.harvard.edu rsrokosh@bidmc.harvard.edu challer@bidmc.harvard.edu jchen13@bidmc.harvard.edu edai@bidmc.harvard.edu mailto:echaikof@bidmc.harvard.edu.ORCID https://orcid.org/0000-0001-5801-9052
Erbin DaiDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University Boston MA USA echaikof@bidmc.harvard.edu rsrokosh@bidmc.harvard.edu challer@bidmc.harvard.edu jchen13@bidmc.harvard.edu edai@bidmc.harvard.edu mailto:echaikof@bidmc.harvard.edu.
Ruiqing XiaoDepartments of Chemistry, Biomedical Engineering, and Medicine, Boston University Boston MA 02215 USA mgrin@bu.edu mariavar@bu.edu stacy.chin@hydroglydecoatings.com xiaorq@mit.edu.ORCID https://orcid.org/0000-0001-7944-0508
Elliot L ChaikofDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University Boston MA USA echaikof@bidmc.harvard.edu rsrokosh@bidmc.harvard.edu challer@bidmc.harvard.edu jchen13@bidmc.harvard.edu edai@bidmc.harvard.edu mailto:echaikof@bidmc.harvard.edu.ORCID https://orcid.org/0000-0001-6184-4571
Mark W GrinstaffDepartments of Chemistry, Biomedical Engineering, and Medicine, Boston University Boston MA 02215 USA mgrin@bu.edu mariavar@bu.edu stacy.chin@hydroglydecoatings.com xiaorq@mit.edu.ORCID https://orcid.org/0000-0002-5453-3668
Beth Israel Deaconess Medical Center · USBoston University · US

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical EducationK12HL141953 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAIKOF, ELLIOT, CUMMINGS, RICHARD D · 2018 to 2022
$4.8M
NHLBI NIH HHS K12 HL141953NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

Anticoagulant therapeutics are a mainstay of modern surgery and of clotting disorder management such as venous thrombosis, yet performance and supply limitations exist for the most widely used agent - heparin. Herein we report the first synthesis, characterization, and performance of sulfated poly-amido-saccharides (sulPASs) as heparin mimetics. sulPASs inhibit the intrinsic pathway of coagulation, specifically FXa and FXIa, as revealed by

Identifiers

PMID34703558
PMCPMC8494039
OpenAlexW3196894246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.