Evidence map›Paper›PMID 34703432›Full record

ArticleCase reports in oncology

Serial Cancer Development Three Times in a Patient with Fanconi Anemia.

Katsuya Yanagisawa, Toshimichi Horiuchi, Akemi Matsuo, Hiroshi Kuraishi, Hidetoshi Satomi, Ichiro Ito, Takuro Noguchi, Nodoka Sekiguchi, Shintaro Kanda, Tomonobu Koizumi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. High-Power Laser Treatment for Oral Leukoplakia in Fanconi Anemia: A Case Series Report.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Katsuya YanagisawaDepartment of Pulmonary Medicine, Minami Nagano Iryou Center, Shinonoi Hospital, Nagano, Japan.
Toshimichi HoriuchiDepartment of Pulmonary Medicine, Minami Nagano Iryou Center, Shinonoi Hospital, Nagano, Japan.
Akemi MatsuoDepartment of Pulmonary Medicine, Minami Nagano Iryou Center, Shinonoi Hospital, Nagano, Japan.
Hiroshi KuraishiDepartment of Pulmonary Medicine, Nagano Red Cross Hospital, Nagano, Japan.
Hidetoshi SatomiDepartment of Pathology, Nagano Red Cross Hospital, Nagano, Japan.
Ichiro ItoDepartment of Pathology, Nagano Red Cross Hospital, Nagano, Japan.
Takuro NoguchiDepartment of Hematology and Medical Oncology, Shinshu University School of Medicine, Matsumoto, Japan.
Nodoka SekiguchiDepartment of Hematology and Medical Oncology, Shinshu University School of Medicine, Matsumoto, Japan.
Shintaro KandaDepartment of Hematology and Medical Oncology, Shinshu University School of Medicine, Matsumoto, Japan.
Tomonobu KoizumiDepartment of Hematology and Medical Oncology, Shinshu University School of Medicine, Matsumoto, Japan.
Shinshu University · JPNagano Red Cross Hospital · JPShinonoi General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fanconi anemia (FA) is characterized clinically by bone marrow failure, congenital malformations, sensitivity to DNA cross-linking agents, and increased risk of malignancy. Hematological cancer is the best-described malignancy in patients with FA, but the susceptibility to the development of solid tumors is also well documented, especially after hematopoietic stem cell transplantation (HSCT). With regard to the development of solid tumors in patients with FA, head and neck, esophageal, and anal squamous cell carcinoma are well known, but reports of lung cancer are extremely rare. Here, we describe an FA patient with a history of HSCT that developed 3 serial cancers - oral, esophageal, and nonsmall cell lung cancer - over a period of 6 years. The third lesion was nonsmall cell lung cancer and its location corresponded closely to the field of irradiation treatment for prior esophageal cancer. The occurrence of lung cancer in patients with FA is uncommon, but FA patients should be screened regularly and serially. Our case also indicated the importance of the irradiated field as a location for subsequent cancer development.

Indexed as

Fanconi anemiaHematopoietic stem cell transplantationLung cancerRadiotherapySecondary malignancySquamous cell carcinoma

Identifiers

PMID34703432
PMCPMC8460962
OpenAlexW3196532613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.