Evidence map›Paper›PMID 34703426›Full record

ArticleCase reports in dermatology

Topical Tofacitinib: A Janus Kinase Inhibitor for the Treatment of Vitiligo in an Adolescent Patient.

Sineida Berbert Ferreira, Rachel Berbert Ferreira, Afonso Cesar Neves Neto, Silvana Martins Caparroz Assef, Morton Scheinberg

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Tofacitinib as a Promising Therapeutic Option for Vitiligo: A Systematic Review.Clinical, cosmetic and investigational dermatology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Vitiligo: Pathogenesis and New and Emerging Treatments.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. JAK-STAT pathway inhibitors in dermatology.Anais brasileiros de dermatologia
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sineida Berbert FerreiraPrivate Dermatologic Clinic, Maringá, Brazil.
Rachel Berbert FerreiraCEPED - Centro Paranaense de Estudos em Dermatologia, Maringá, Brazil.
Afonso Cesar Neves NetoUNICESUMAR - Centro Universitario de Maringá, Maringá, Brazil.
Silvana Martins Caparroz AssefCEPED - Centro Paranaense de Estudos em Dermatologia, Maringá, Brazil.
Morton ScheinbergHospital Israelita Albert Einstein - Rheumatology and Orthopedic Division, São Paulo, Brazil.
Centro Universitário Cesumar · BRBeneficência Portuguesa de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitiligo is an autoimmune skin disease presenting with areas of depigmentation. Recent reports suggest that Janus kinase (JAK) inhibitors may be an effective therapy. In this case report, we show our experience with an adolescent patient with a long history of generalized and refractory vitiligo, for which treatment with topical tofacitinib, a JAK inhibitor, associated with phototherapy for 9 months, resulted in near complete repigmentation.

Indexed as

AdolescentJAK inhibitorJanus kinase inhibitorPhototherapyTofacitinibTopical tofacitinibTreatmentVitiligo

Identifiers

PMID34703426
PMCPMC8488419
OpenAlexW3145529239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.