ArticleJournal of cytology
Fine-Needle Aspiration Diagnosis of Lymphoma Based on Cytomorphology Alone: How Accurate is it? - A Cyto-Histopathology Correlative Study.
Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Bridging Cytology and Histology: Concordance Analysis of Lymph Node Lesions within the Sydney Framework.Iranian journal of pathology · 2026Article
- Institutional Experience of Lymphoproliferative Disorders with Initial Diagnosis Made via Fine Needle Aspiration at Otolaryngology Clinic.Acta medica academica · 2024Article
- Article
- Pitfalls in Lymph Node Fine Needle Aspiration Cytology.Acta cytologica · 2024Review
- Ultrasonographic and cytological characterization of ultrasound-guided fine-needle aspiration cytology of cervical lymph nodes for false-negative and false-positive diagnosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Utility and Limitations of Fine-Needle Aspiration Cytology in the Diagnosis of Lymphadenopathy.Diagnostics (Basel, Switzerland) · 2023Article
- Review
- Role of Polyamines as Biomarkers in Lymphoma Patients: A Pilot Study.Diagnostics (Basel, Switzerland) · 2022Article
- Fine Needle Aspirate Flow Cytometry's Ancillary Utility in Diagnosing Non-Hodgkin Lymphoma in the Head and Neck.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
- Application of the Sydney System for Classification and Reporting Lymph Node Cytopathology to Assess the Risk of Malignancy and its Diagnostic Accuracy.Journal of cytologyArticle
- Evaluation of Fine-Needle Aspiration of Lymph Nodes and Assessment of Risk of Malignancy Based on the Sydney System of Reporting Lymph Node Cytology.Journal of cytologyArticle
- Study of Extramedullary Lymphoblastic Lymphoma (LBL) Diagnosed by Flowcytometric Immunophenotyping (FCI) on Fine Needle Aspirate (FNA) Sample-A Case Series of 18 Cases.Journal of cytologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextFine-needle aspiration cytology (FNAC) is a rapid and accurate first-line diagnostic modality in lymphadenopathy.
aimsTo determine the utility of FNAC for the diagnosis of lymphoma and highlight the various pitfalls in morphological interpretation. SETTINGS AND
designThis was a retrospective study of 3 years duration in which cytology diagnosis was compared with the follow-up histopathology diagnosis wherever available.
resultsA cytodiagnosis of lymphoma was made in a total of 868 cases (2.8%) out of nearly 33,000 FNAC performed during the study period; 556 (64.1%) cases were diagnosed as non-Hodgkin lymphoma (NHL), 198 (22.8%) as Hodgkin lymphoma (HL), and in 114 (13.1%) cases, a cytological diagnosis of lymphoma without further categorization was given. Histopathological reports were available in 348 cases, with an overall concordance rate of 93.1% (324), which was slightly higher in the HL cases (95.8%) as compared to NHL (91.7%). Twenty-four cases (6.9%) showed discordant cytological diagnosis with subsequent histopathology. The main reasons for the erroneous diagnosis were the over-interpretation of the germinal center cells as atypical lymphoid cells, over-interpretation of immunoblasts with prominent nucleoli as Hodgkin cells, and sheets of monomorphic lymphoid cells interpreted as low-grade lymphoma.
conclusionCytomorphology alone can make a correct basic diagnosis of lymphoma with a high degree of accuracy. The errors in interpretation can be further reduced by careful attention to the diagnostic pitfalls and common differential diagnoses.
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