ArticleMolecular psychiatry2022
Common and differential connectivity profiles of deep brain stimulation and capsulotomy in refractory obsessive-compulsive disorder.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Neural basis of successful DBS for OCD after failed capsulotomy.medRxiv : the preprint server for health sciences · 2026Article
- Neuroimaging in lesioning therapy for obsessive-compulsive disorder: region-based and network analysis of preoperative outcome predictors and postoperative effects.NeuroImage. Clinical · 2026Review
- Functional brain network alterations in a rat model of dental malocclusion.Frontiers in neuroscience · 2026Article
- Altered anterior cingulate cortex functional connectivity in treatment-naïve obsessive-compulsive disorder: a resting-state fMRI study.Frontiers in psychiatry · 2026Article
- Mechanisms of DBS: from informational lesions to circuit modulation and implications in OCD.Frontiers in human neuroscience · 2025Review
- Quantitative Expression of Latent Disease Factors in Individuals Associated with Psychopathology Dimensions and Treatment Response.Neuroscience bulletin · 2024Article
- State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model.Nature communications · 2023Article
- Dissecting Psychiatric Heterogeneity and Comorbidity with Core Region-Based Machine Learning.Neuroscience bulletin · 2023Review
- Landscape and future directions of machine learning applications in closed-loop brain stimulation.NPJ digital medicine · 2023Review
- A Systematic Review of Treatment Outcome Predictors in Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder.Brain sciences · 2022Review
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
Neurosurgical interventions including deep brain stimulation (DBS) and capsulotomy have been demonstrated effective for refractory obsessive-compulsive disorder (OCD), although treatment-shared/-specific network mechanisms remain largely unclear. We retrospectively analyzed resting-state fMRI data from three cohorts: a cross-sectional dataset of 186 subjects (104 OCD and 82 healthy controls), and two longitudinal datasets of refractory patients receiving ventral capsule/ventral striatum DBS (14 OCD) and anterior capsulotomy (27 OCD). We developed a machine learning model predictive of OCD symptoms (indexed by the Yale-Brown Obsessive Compulsive Scale, Y-BOCS) based on functional connectivity profiles and used graphic measures of network communication to characterize treatment-induced profile changes. We applied a linear model on 2 levels treatments (DBS or capsulotomy) and outcome to identify whether pre-surgical network communication was associated with differential treatment outcomes. We identified 54 functional connectivities within fronto-subcortical networks significantly predictive of Y-BOCS score in patients across 3 independent cohorts, and observed a coexisting pattern of downregulated cortico-subcortical and upregulated cortico-cortical network communication commonly shared by DBS and capsulotomy. Furthermore, increased cortico-cortical communication at ventrolateral and centrolateral prefrontal cortices induced by DBS and capsulotomy contributed to improvement of mood and anxiety symptoms, respectively (p < 0.05). Importantly, pretreatment communication of ventrolateral and centrolateral prefrontal cortices were differentially predictive of mood and anxiety improvements by DBS and capsulotomy (effect sizes = 0.45 and 0.41, respectively). These findings unravel treatment-shared and treatment-specific network characteristics induced by DBS and capsulotomy, which may facilitate the search of potential evidence-based markers for optimally selecting among treatment options for a patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.