ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Postpartum scarcity-adversity disrupts maternal behavior and induces a hypodopaminergic state in the rat dam and adult female offspring.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Postpartum scarcity-adversity increases adverse caregiving in the absence of basal corticosterone elevation.Psychoneuroendocrinology · 2025Article
- Stress and parental behaviors.Neuroscience research · 2025Review
- Female rats exposed to early life scarcity-adversity are resilient to later life changes in maternal behavior.Hormones and behavior · 2025Article
- Gestational stress disrupts dopamine and oxytocin signaling in the postpartum reward system of rats: implications for mood, motivation and mothering.Scientific reports · 2025Article
- Sex- and reward-dependent effects of early life scarcity-adversity on adolescent behavioral responses to natural rewards.Frontiers in behavioral neuroscience · 2025Article
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- Stress-induced modulation of maternal behavior and mesolimbic dopamine function.Current opinion in behavioral sciences · 2024Article
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
- Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice.Journal of visualized experiments : JoVE · 2024Article
- CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats.Neurobiology of stress · 2024Article
- Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence.Pharmacology, biochemistry, and behavior · 2023Article
- Early life stress, prenatal secondhand smoke exposure, and the development of internalizing symptoms across childhood.Environmental health : a global access science source · 2023Article
- Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.Addiction neuroscience · 2023Article
- Prefrontal cortex neurons in adult rats exposed to early life stress fail to appropriately signal the consequences of motivated actions.Physiology & behavior · 2023Article
- Manifestations of Intergenerational Trauma During the Perinatal Period Among Adolescent Mothers in Lima, Peru: A Qualitative Analysis.Journal of child & adolescent trauma · 2023Article
- Editorial: Translational behavioral approaches in animal models of psychiatry.Frontiers in behavioral neuroscience · 2023Article
- Dopamine downregulation in novel rodent models useful for the study of postpartum depression.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Postpartum adversity is among the strongest predictors for the emergence of postpartum depression (PPD) in humans and a translational risk factor employed in rodent models. Parental care is disturbed under conditions of environmental adversity, including low resource environments, and in PPD. Nonetheless, the neural changes associated with these adversity-induced maladaptive behavioral states remain poorly understood. Postpartum scarcity-adversity can be modeled in rats by providing the dam with limited bedding and nesting (LBN) materials, which mimics the effects of a stressful low resource environment in potentiating maltreatment/neglect in humans. Indeed, LBN exposure from postpartum days (PD) 2-9 increased adverse maternal behaviors, impaired pup retrieval, and increased passive stress coping responses. Since mesolimbic dopamine (DA) activity is an important mechanism for motivated maternal behavior and is implicated in PPD, we assessed the impact of postpartum scarcity-adversity on in vivo electrophysiological properties of ventral tegmental area (VTA) DA neurons at two timepoints. We found reduced numbers of active VTA DA neurons in LBN dams at PD 9-10 but not PD-21, suggesting a transient impact on VTA population activity in LBN dams. Finally, we assessed the impact of early life scarcity-adversity on VTA DA function by conducting VTA recordings in adult female offspring and found a long-lasting attenuation in DA activity. These findings highlight a link between adversity-induced deficits in DA function and disrupted maternal behavior, suggesting the VTA/mesolimbic DA system as a potential mechanism by which postpartum scarcity-adversity drives aberrant maternal behavior, and early postnatal programming of adult VTA function in the offspring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.