Evidence map›Paper›PMID 34702947›Full record

ArticleCell research2022

K

Tobias Ruck, Stefanie Bock, Steffen Pfeuffer, Christina B Schroeter, Derya Cengiz, Paul Marciniak, Maren Lindner, Alexander Herrmann, Marie Liebmann, Stjepana Kovac and 28 more

Open access · hybridAbstract read
In one paragraph

Article in Cell research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Structure-Function Relationships of KAdvances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. The potassium channel KNature communications · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. TLR4 induced TRPM2 mediated neuropathic pain.Frontiers in pharmacology · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Dietary regulation in health and disease.Signal transduction and targeted therapy · 2022
    Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 7 institutions in 2 countries.

Tobias Ruck *Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. tobias.ruck@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0001-6332-8650
Stefanie Bock *Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Steffen PfeufferDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Christina B SchroeterDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Derya CengizDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Paul MarciniakDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Maren LindnerDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Alexander HerrmannDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Marie LiebmannDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Stjepana KovacDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Lukas GolaDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Leoni RolfesDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Marc PawlitzkiDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Nils OpelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Thomas PapInstitute of Experimental Musculoskeletal Medicine (IMM), University of Münster, Münster, Germany.
Felix LuessiDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Julian A SchreiberInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-3847-7539
Bernhard WünschInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany.
Tanja KuhlmannInstitute of Neuropathology, University of Münster, Münster, Germany.
Guiscard SeebohmCellular Electrophysiology and Molecular Biology, Institute for Genetics of Heart Diseases (IfGH), University of Münster, Münster, Germany.
Björn TackenbergDepartment of Neurology, Philipps-University, Marburg, Germany.
Patricia SejaLaboratory of Neurobiology, University of Helsinki, Helsinki, Finland.
Frank DöringMolecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany.
Erhard WischmeyerMolecular Electrophysiology, Institute of Physiology and Center of Mental Health, University of Würzburg, Würzburg, Germany.
Achmet Imam ChasanInstitute of Immunology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-5137-6890
Johannes RothInstitute of Immunology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7035-8348
Luisa KlotzDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-5439-9633
Gerd Meyer Zu HörsteDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-4341-4719
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-4310-3432
Tobias MarschallInstitute for Medical Biometry and Bioinformatics, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-9376-1030
Stefan FloessDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Jochen HuehnDepartment of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Thomas BuddeInstitute for Physiology I, University of Münster, Münster, Germany.
Tobias BoppInstitute of Immunology, Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-3232-8065
Stefan BittnerDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Sven G MeuthDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
University of Münster · DEHeinrich Heine University Düsseldorf · DEJohannes Gutenberg University Mainz · DEHelmholtz Centre for Infection Research · DEUniversity of Würzburg · DEPhilipps University of Marburg · DEUniversity of Helsinki · FI

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) CRC-TR-128Deutsche Forschungsgemeinschaft (German Research Foundation) RTG 2515Deutsche Forschungsgemeinschaft (German Research Foundation) SFB BI1822/1-1
6 · The paper itself

Abstract

It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the cell fate decisions towards conventional (Tconv) or regulatory T cells (Treg). Following TCR activation, intracellular calcium (Ca

Indexed as

Potassium ChannelsReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryAnimalsCell DifferentiationForkhead Transcription FactorsHumansMiceNF-kappa BThymocytesThymus GlandForkhead Transcription FactorsNF-kappa BPotassium ChannelsReceptors, Antigen, T-Cell

Identifiers

PMID34702947
PMCPMC8547300
OpenAlexW3209954021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.